红细胞输注疗效和铁过载对再生障碍性贫血患者T淋巴细胞亚群的影响

Effect of Red Blood Cell Infusion and Iron Overload on T Lymphocyte Subsets of Aplastic Anemia Patients

目的 浅析红细胞输注疗效和铁过载再生障碍性贫血患者对T淋巴细胞亚群的影响,以便为日后临床提供参考。方法 选取2022年1—12月北大医疗鲁中医院收入的再生障碍性贫血患者68例为研究对象,依据输注是否有效分为输注有效组与输注无效组,每组34例,分析两组患者的T淋巴细胞亚群的结果。结果 两组患者T淋巴细胞检验结果指标相比,差异无统计学意义(P>0.05);输血有效组及输血无效组患者非铁过载患者CD3+指标均高于铁过载,差异有统计学意义(P<0.05)。结论 患者长期依靠红细胞输注会造成铁过载,而铁过载会对CD3+T淋巴细胞产生影响,特别是在红细胞输注是有效的情况下。

Objective To analyze curative effect of red blood cell infusion and iron overload on T lymphocyte subsets of aplastic anemia patients,and provide reference for future clinical practice.Methods The paper chose 68 patients with aplastic anemia admitted to a hospital from January 2022 to December 2022,and divided them into effective infusion group and ineffective infusion group based on effective infusion,with 34 cases in each group.Result? of T lymphocyte subsets in both groups were analyzed.Results Difference in T lymphocyte test between two groups was not statistically significant(P>0.05).CD3+index of non iron overload patients in effective and ineffective transfusion groups was higher than iron overload patients,difference was statistically significant(P<0.05).Conclusion Long term reliance on red blood cell infusion can cause iron overload of patients,and iron overload can achieve effect on CD3+T lymphocytes,especially when red blood cell infusion is effective.