超脉冲CO_(2)点阵激光联合他克莫司软膏治疗白癜风效果观察

Curative Effect Observation of Superpulse CO_(2) Lattice Laser Combined with Tacrolimus Ointment in Treatment of Vitiligo

目的 分析超脉冲CO_(2)点阵激光联合他克莫司软膏在治疗白癜风的效果。方法 选取2020年5月—2022年12月本院收治的92例白癜风患者作为研究对象,并按照随机抽签方式分为对照组和观察组,每组46例。对照组采取常规外用药治疗(他克莫司软膏治疗),观察组在此基础上联合超脉冲CO_(2)点阵激光,分析治疗后的临床疗效、色素评分、皮损面积、QOL(生活质量)、不良反应发生率的情况。结果 治疗前,两组的皮损和色素评分及生活质量评分对比差异没有统计学意义(P>0.05);治疗后,观察组的总临床有效率、生活质量、色素评分高于对照组,且观察组的皮损面积、总不良反应发生率低于对照组,两组之间的比较差异有统计学意义(P<0.05)。结论 在白癜风的治疗中应用超脉冲CO_(2)点阵激光联用他克莫司软膏,能提升患者的临床效果,促进色素恢复,减少皮损面积,在临床上值得推广。

Objective To analyze effect of ultra pulsed CO_(2) lattice laser combined with tacrolimus ointment in treatment of vitiligo.Methods The paper chose 92 vitiligo patients admitted to our hospital from May 2020 to December 2022 as study subjects,and divided them into two groups randomly,with 46 cases in each group.Control group was treated with routine topical tacrolimus ointment,while observation group with ultra pulsed CO_(2) dot matrix laser.Clinical Effect,pigment scores,lesion area,QOL(life quality),and incidence of adverse reactions were analyzed after treatment.Results There was no statistically significant difference in scores of skin lesions,pigmentation,and life quality between two groups before treatment(P>0.05).After treatment,total clinical effective rate,life quality,and pigmentation scores of observation group were higher than control group,skin lesion area and total incidence of adverse reactions in observation group was lower than control group,difference was statistically significant between two groups(P<0.05).Conclusion Ultra pulsed CO_(2) lattice laser combined with tacrolimus ointment can improve disease knowledge,promote pigment recovery,and reduce skin lesion area of vitiligo patients,which is recommended in clinical practice.