盐酸羟考酮缓释片联合奥氮平在癌性内脏痛患者治疗中的应用效果及可行性分析

Application Effect and Feasibility Analysis of Hydroxycodone Hydrochloride Sustained-Release Tablets Combined with Olanzapine in Treatment of Cancerous Visceral Pains

目的探讨盐酸羟考酮缓释片联合奥氮平在癌性内脏痛患者治疗中的应用效果及可行性。方法选取2021年10月—2023年10月本院收治的80例癌性内脏痛患者展开研究,采用随机数字表法进行平均分组,常规组、联合组每组40例,常规组仅采用常规羟考酮缓释片止痛治疗,联合组在常规组的基础上联合奥氮平治疗,对比两组患者的临床治疗效果和质量。结果和常规组相比,联合组患者的治疗有效率明显更高,差异有统计学意义(P<0.05)。治疗前,对比两组患者QOL评分,差异无统计学意义(P>0.05);治疗后,两组QOL评分均有所上升,但联合组患者评分明显高于常规组,差异有统计学意义(P<0.05)。结论盐酸羟考酮缓释片联合奥氮平对癌性内脏痛患者具有积极意义,减轻了患者的疼痛,提高了临床治疗效率和患者生活质量,值得临床应用。

Objective To explore application effect and feasibility of hydroxycodone hydrochloride sustained-release tablets combined with olanzapine in treatment of cancerous visceral pain patients.Methods The paper chose 80 patients with cancerous visceral pain admitted to our hospital from October 2021 to October 2023,and divided them into two groups in average with random number table method,with 40 cases in routine group and 40 cases in combination group.The former was treated with routine hydroxycodone sustained-release tablets only for pain relief,while the latter combined with olanzapine on the basis of the former.Clinical curative effect and quality between two groups was compared.Results Combination group had significantly higher treatment effect rate than routine group,difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in QOL scores between two groups(P>0.05).After treatment,both groups showed increase in QOL scores,but combination group had significantly higher scores than routine group,with statistically significant difference(P<0.05).Conclusion Combination of hydroxycodone hydrochloride sustained-release tablets and olanzapine can achieve positive effect on patients with cancerous visceral pain,alleviate pain degree,enhance clinical treatment efficiency,and improve life quality of patients,which is worthy of clinical application in future.