多索茶碱联合喷托维林对老年阻塞性睡眠呼吸暂停低通气综合征的干预效果分析

Interventional Effect Analysis of Doxophylline Combined with Pentavirin on Elderly Obstructive Sleep Apnea Hypopnea Syndrome

目的 分析多索茶碱联合喷托维林对老年阻塞性睡眠呼吸暂停低通气综合征患者的干预效果。方法 选取2020年3月—2022年6月本院收治的168例老年阻塞性睡眠呼吸暂停低通气综合征患者为研究对象,随机将其分为对照组(84例,给予喷托维林治疗)和治疗组(84例,在对照组的基础上给予多索茶碱治疗),对比两组患者嗜睡程度[Epworth嗜睡量表(ESS)]、睡眠质量[匹兹堡睡眠质量指数量表(PSQI)]、鼻塞程度[鼻阻塞症状评估量表(NOSE)]、通气情况[睡眠呼吸暂停低通气指数(AHI)]以及缺氧程度[夜间血氧饱和度(MSaO_(2))]情况、临床疗效、安全性、炎症因子水平。结果 治疗后,治疗组患者治疗总有效率明显高于对照组(P<0.05)。治疗后,治疗组患者ESS、PSQI、NOSE评分以及AHI水平均低于对照组,且MSaO_(2)高于对照组(P<0.05)。治疗后,治疗组患者CRP、IL-6水平均低于对照组(P<0.05)。治疗后,两组患者不良反应总发生率无明显差异(P>0.05)。结论 多索茶碱联合喷托维林能够降低患者炎症因子水平,改善睡眠质量、鼻塞、嗜睡、缺氧情况,提高临床疗效。

Objective To analyze intervention effect of Doxophylline combined with Pentavirin on elderly patients with obstructive sleep apnea hypopnea syndrome.Methods The paper chose 168 elderly patients with obstructive sleep apnea hypopnea syndrome admitted to our hospital from March 2020 to June 2022,and divided them into control group(84 cases,treated with pentavirin)and treatment group(84 cases,with doxorubicin on the basis of control group)randomly.Degree of drowsiness Epworth Sleepiness Scale(ESS)and sleep quality Pittsburgh Sleep Quality Index(PSQI),degree of nasal congestion Nose Obstruction Symptom Evaluation Scale(NOSE),ventilation status Sleep Apnea Hypoventilation Index(AHI),and degree of hypoxia Nighttime Blood Oxygen saturation(MSaO_(2)),clinical effect,safety,and levels of inflammatory factors were compared between two groups.Results After treatment,total effective rate of treatment group was significantly higher than control group(P<0.05).After treatment,ESS,PSQI,NOSE scores,and AHI levels of both groups were lower than control group,and MSaO_(2) was higher than control group(P<0.05).After treatment,average levels of CRP and IL-6 in treatment group were lower than control group(P<0.05).After treatment,there was no significant difference in total incidence of adverse reactions between two groups(P>0.05).Conclusion Combination of Doxophylline and Pentavirin can reduce levels of inflammatory factors,improve sleep quality,nasal congestion,drowsiness,and hypoxia,and enhance clinical effect of patients.