泛素特异性蛋白酶在胃癌中的作用研究进展

Research progress on role of ubiquitin-specific proteases in gastric cancer

泛素特异性蛋白酶(USPs)是去泛素化酶家族诸多亚族之一,具有多种功能结构域和生物学功能,可通过泛素与蛋白底物解离来调控泛素化,从而调控细胞的凋亡、增殖、转移以及基因转录、间充质转化和免疫反应等。泛素是一种标记将要分解的蛋白质并存在于大多数真核细胞的小蛋白,其通过泛素化复合链式反应,使蛋白质水解。泛素化复合式链式反应存在不同位点,USPs可以作用于其位点,并影响生物体内的泛素化,对蛋白质的降解起到不同作用。USPs在多种肿瘤中表达,并通过一系列机制参与肿瘤发生发展,可作为癌症治疗靶点。本文就USPs在胃癌中的作用研究进展进行综述,以期为以USPs为靶点的胃癌治疗新药的研发提供资料。

Ubiquitin-specific proteases(USPs)are one of the many subfamilies of the deubiquitinating enzyme family,with a variety of functional structural domains and biological functions,which can regulate ubiquitination through the dissociation of ubiquitin from protein substrates,thereby regulating apoptosis,proliferation,metastasis,as well as gene transcription,mesenchymal transition,and immune responses.Ubiquitin is a small protein that marks proteins for degradation and is present in most eukaryotic cells,which hydrolyses proteins through a complex chain reaction of ubiquitination.There are different sites of ubiquitination complex chain reactions,and USPs can act on them and affect ubiquitination in organisms,playing different roles in protein degradation.USPs are expressed in a variety of tumors and participate in tumorigenesis and development through a series of mechanisms,which can be used as cancer therapeutic targets.This article reviews the progress of research on the role of USPs in gastric cancer,in order to provide information for the development of new drugs targeting USPs for the treatment of gastric cancer.