胺碘酮对预防冠状动脉旁路移植术后心房颤动的临床观察

Clinical Efficacy of Amiodarone in the Prevention of Atrial Fibrillation after Coronary Artery Bypass Grafting

目的:探讨术后预防性给予胺碘酮对冠状动脉旁路移植术术后患者心房颤动发生率的影响。方法:选择择期行冠状动脉旁路移植术的患者68例,随机分为观察组和对照组各34例。对照组给予冠心病常规治疗药物,观察组在常规药物的基础上应用胺碘酮,比较2组患者术后房颤发生情况。结果:观察组术后房颤发生率(14.70%)明显低于对照组(35.29%),差异有统计学意义(P<0.05);观察组房颤时最大心室率为[130.0(6.00)]次·min-1,对照组为[150.5(32.75)]次·min-1,观察组明显慢于对照组(P<0.05);对照组术后平均心率明显高于观察组(P<0.05)。结论:胺碘酮对冠状动脉旁路移植术后房颤的预防治疗起到积极作用,能够有效降低术后房颤发生率。

Objective:To investigate the effect of postoperative prophylactic administration of amiodarone on the incidence of atrial fibrillation in patients after coronary artery bypass grafting.Methods:A total of 68 patients undergoing elective coronary artery bypass grafting were randomly divided into the experimental group and the control group,with 34 cases in each group.The control group was given conventional treatment for coronary heart disease,and the experimental group was treated with amiodarone based on conventional treatment,and the differences in the occurrence of postoperative atrial fibrillation between the two groups were com-pared.Results:The incidence of postoperative atrial fibrillation in the experimental group(14.70%)was significantly higher than that in the control group(35.29%),and the difference was statistically significant(P<0.05).The maximum ventricular rate of at-rial fibrillation[130.0(6.00)]beats/minute,which was significantly slower than that in the control group[150.5(32.75)]beats/minute(P<0.05).The average postoperative heart rate of the control group was significantly higher than that of the experi-mental group(P<0.05).Conclusion:Amiodarone plays a positive role in the prevention and treatment of atrial fibrillation after coronary artery bypass grafting,and can effectively reduce the incidence of postoperative atrial fibrillation.