核因子E2相关因子2在运动改善非酒精性脂肪性肝病中的作用

The Role of Nrf2 in Exercise Improving of NAFLD

核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)信号通路在维持心血管疾病、神经系统退行性疾病以及慢性代谢性疾病中的细胞稳态方面起关键作用。研究表明,以氧化应激、炎症和线粒体功能失调为特征的慢性疾病可通过增加Nrf2表达来恢复机体氧化还原状态,治疗或预防疾病。非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是一种由除酒精以外的其他多种因素导致的以肝脏脂肪变性为特征的慢性代谢性肝脏疾病,其患病率近年来在全球范围内逐渐增加。运动是防治NAFLD的有效手段,可通过运动方式、运动强度、运动环境和运动疲劳等因素影响Nrf2信号通路。本文通过阐述Nrf2信号通路的激活、其调控抗氧化的相关机制以及运动对Nrf2信号通路的影响,以NAFLD的发病机制为基础,探讨运动、Nrf2和NAFLD之间的关系,综述Nrf2在运动改善NAFLD中的作用及相关机制。为运动改善NAFLD的分子机制研究提供理论参考依据。

In cardiovascular disorders,neurological diseases,and chronic metabolic diseases,the nuclear factor erythroid 2-related factor 2(Nrf2)signaling pathway is essential for maintaining cell homeostasis.According to studies,boosting Nrf2 expression can be used to cure or prevent chronic diseases that are characterized by oxidative stress,inflammation,and mitochondrial dysfunction.Nonalcoholic fatty liver disease(NAFLD)is a chronic metabolic liver disease characterized by hepatic steatosis brought on by a number of causes other than alcohol.In recent years,its incidence has gradually risen across the globe.According to relevant studies,NAFLD and the Nrf2 signaling pathway are tightly connected.Inhibiting lipid production and metabolism-related enzymes,repairing impaired liver metabolism,and lowering hepatic lipid storage are all possible with Nrf2 activation.Exercise is a powerful tool for treating and preventing NAFLD.However,exercise type,exercise intensity,environment,and exhaustion all have an impact on the Nrf2 signaling pathway.By activating Nrf2,exercise can lessen liver inflammation,oxidative stress,endoplasmic reticulum stress,and insulin resistance,and ameliorate liver damage to improve NAFLD.The activation of Nrf2 signaling pathway,its associated mechanism of controlling antioxidation,and the impact of exercise on the Nrf2 signaling pathway are all explained in this work.Based on the pathogenesis of NAFLD,this article examines the connection between exercise,Nrf2,and NAFLD,and the current state of knowledge regarding Nrf2’s role in the amelioration of NAFLD through exercise.It offers a theoretical frame of reference for future research into how Nrf2 might be used to improve NAFLD.