miR⁃21、NF⁃κB联合检测对甲状腺乳头状癌复发风险的评估价值

The Value of Combined Detection of miR⁃21 and NF⁃κB in Evaluating the Risk of Recurrence in Patients with Papillary Thyroid Carcinoma

目的:探讨微小核糖核酸-21(miR⁃21)、核因子-κB(NF⁃κB)联合检测对甲状腺乳头状癌(PTC)患者复发风险的评估价值。方法:纳入2021年1月至2022年10月期间广东省佛山市顺德区第三人民医院收治的甲状腺乳头状癌患者80例为研究对象,根据出院后随访1年的复发情况分为复发组(n=23)与非复发组(n=57)。以多因素Logistic回归分析血清miR⁃21、NF⁃κB与PTC患者复发风险的相关性,并绘制受试者工作特性曲线(ROC)进一步评估联合miR⁃21、NF⁃κB检测对PTC患者复发风险的预测价值。结果:两组患者在年龄、病理学分期、肿瘤大小、有无颈淋巴结转移以及miR⁃21、NF⁃κB表达水平方面的比较差异显著(P<0.05);多因素Logistic回归分析结果显示年龄>55岁、有淋巴结转移、miR⁃21、NF⁃κB表达水平的升高均为影响PTC患者复发风险的独立危险因素。ROC曲线显示miR⁃21、NF⁃κB及二者联合检测曲线下面积为0.895、0.895及0.960。结论:miR⁃21、NF⁃κB表达水平的上调与PTC患者术后复发风险密切相关,且联合检测具备更高预测价值,可作为临床评估PTC患者术后复发风险的有效预测指标。

Objective:To investigate the value of combined detection of miR⁃21 and NF⁃κB in evaluating the recurrence risk of PTC patients.Methods:80 patients with papillary thyroid carcinoma admitted to the Third People's Hospital of Shunde District,Foshan City,Guangdong Province from Jan 2021 to Oct 2022 were included in the study.According to the recurrence situation of patients 1 year after discharge,they were divided into a recurrence group(n=23)and a non⁃recurrence group(n=57).Multivariate Logistic regression was used to analyze the correlation between serum miR⁃21 and NF⁃κB and the risk of relapse in PTC patients,and ROC curve was drawn to evaluate the predictive value of combined detection of Mir⁃21 and NF⁃κB on the risk of relapse in PTC patients.Results:There were significant differences in miR⁃21 and NF⁃κB levels in age,pathological stage,tumor size and cervical lymph node metastasis between the two groups(P<0.05).Multivariate analysis showed that age>55 years,lymph node metastasis,miR⁃21 and NF⁃κB expression were independent risk factors for relapse in PTC patients.ROC curves show that miR⁃21,the nf⁃kappa B and the joint detection area under the curve is 0.895,0.895 and 0.960.Conclusion:The up⁃regulation of miR⁃21 and NF⁃κB levels is associated with the risk of postoperative recurrence in PTC patients,and the combined detection has higher predictive value,and can be used as an effective index to assist clinical evaluation of postoperative recurrence risk in PTC patients.