职业噪声暴露人群额叶脑网络功能连通性研究

Functional Connectivity of Frontal Brain Network in Occupational Noise-Exposed Population

目的 采用功能性近红外线光谱技术(functional near-infrared spectroscopy,fNIRS)探讨健听的职业噪声暴露人群额叶脑网络功能连通性(functional connectivity,FC)的特征。方法 对2023年6月~2023年11月中国某运输公司符合纳入标准的受试者进行脑网络FC、纯音听阈、声阻抗、血糖、血压及焦虑抑郁进行测试。结果 噪声组和对照组性别、年龄、血压、血糖、医院焦虑抑郁量表-抑郁分量表(hospital anxiety and depression scale-depression subscale,HADS-D)评分无差异;噪声组医院焦虑抑郁量表-焦虑分量表(hospital anxiety and depression scale-anxiety subscale,HADS-A)评分高于对照组。噪声组的HADS-A主要集中在正常状态和临界程度,而对照组主要集中在正常状态。噪声组的额叶FC高于对照组,噪声组的额叶静息态HBO高于对照组。噪声暴露时间与额叶FC呈正相关。噪声组额叶FC与医院焦虑抑郁量表-焦虑分量表(hospital anxiety and depression scale-anxiety subscale,HADS-A)得分呈正相关。结论 职业噪声暴露人群在听力出现异常前已经出现了脑功能改变和临床症状;随着噪声暴露时间的增加,脑网络功能改变更加明显;职业噪声暴露人群焦虑与脑网络FC的变化有一定相关性;基于fNIRS的额叶脑网络研究可为职业噪声暴露人群全脑网络的研究提供理论基础,为职业噪声人群的非听觉扩大预防工作提供依据。

Objective The aim of this study is to investigate the functional connectivity(FC)of frontal lobe network in occupational noise-exposed workers with normal hearing using functional near-infrared spectroscopy(fNIRS).Methods From June to November 2023,subjects who met the inclusion criteria in a transportation company in China were tested for brain network FC test,pure tone audiometry test,acoustic impedance test,blood glucose test,blood pressure test,anxiety and depression.Results There was no difference in gender,age,blood pressure,blood glucose and HADS-D between the exposed group and the control group.The HADS-A score of the exposed group was higher than that of the control group.The HADS-A of the exposed group mainly concentrated in the normal state and the critical degree,while that of the control group mainly concentrated in the normal state.The FC of the frontal lobe in the exposed group was higher than that in the control group,and the resting HBO of the frontal lobe in the exposed group was higher than that in the control group.Noise exposure time was positively correlated with FC in frontal lobe.There was A positive correlation between frontal FC and Hospital anxiety and depression scale-anxiety subscale(HDS-A)scores in the exposed group.Conclusion 1.The brain function changes and clinical symptoms of occupational noise-exposed population occur before hearing impairment.With the increase of noise exposure time,the changes of brain network function are more obvious.2.There is a certain correlation between anxiety and the changes of brain network FC in occupational noise exposed population.3.The study of frontal lobe brain network based on fNIRS can provide a theoretical basis for the study of the whole brain network of occupational noise exposure population.