糖脂对痘痘肌的护理功效研究

Research on the skincare effect of glycolipids on acne-prone skin

糖脂属脂类化合物,是一类含有糖基配体的两亲性分子。从抑菌、抗炎、抗敏、控油、舒缓和修复等方面,研究了糖脂在痘痘肌护理中的功效。研究结果显示,糖脂对痤疮丙酸杆菌具有优异的抑菌性能;当糖脂用量达到10μg/mL时,糖脂对SZ95细胞脂质合成的抑制率可达20%;糖脂对LPS诱导的RAW264.7细胞的炎症因子IL-6和NO的释放具有抑制作用;当糖脂浓度为15 mg/mL时,糖脂对透明质酸酶的抑制率达到45.8%;当糖脂浓度为25μg/mL时,对钙离子浓度的抑制率达到45.3%;糖脂对伤口愈合有明显的促进作用。人体功效评价表明,糖脂产品对痘痘肌具备综合护理功效。本研究有助于进一步推动糖脂在化妆品特别是在痘痘肌护肤品中的应用。

Glycolipids are lipid compounds,which are a type of amphiphilic molecules containing glycosyl ligands.This experiment studied the efficacy of glycolipids in acne-prone skin care from the aspects of antibacterial,anti-inflammatory,anti-allergic,oil control,soothing and repairing.The research results show that glycolipids have excellent antibacterial properties against P.acnes.When the dosage of glycolipids reaches 10μg/mL,the inhibition rate of glycolipids on lipid synthesis in SZ95 cells can reach 20%.Glycolipids can have an inhibitory effect on the release of inflammatory factors IL-6 and NO induced by LPS in RAW264.7 cells.When the glycolipid concentration is 15 mg/mL,the inhibition rate of glycolipid on hyaluronidase reaches 45.8%.When the glycolipid concentration is 25μg/mL,the inhibition rate on calcium ion concentration reaches 45.3%.Glycolipids have a significant promoting effect on wound healing.Furthermore,human efficacy evaluation shows that glycolipid products have comprehensive skincare effects on acne-prone skin.This study will help further promote the application of glycolipids in cosmetic products,especially in skin care products for acne-prone skin.