血清中新型冠状病毒抗体检测技术的研究进展

Research Progress of Detection Technology of Anti-SARS-CoV-2 Antibodies in Serum

抗体检测与核酸检测的联合诊断方式在新冠疫情早期流调溯源、感染确诊等方面发挥着重要作用。目前国内外针对新型冠状病毒抗体检测产品的开发主要基于酶联免疫吸附技术、免疫层析技术及化学发光免疫分析技术进行研究,每种检测方法各有优势与不足,在检测性能上也各有差异,相关检测产品相继问世并不断更新优化。本文介绍相关检测方法的检测性能、研究进展等,为临床方法选择、新型抗体检测产品的研究与发展提供参考,推进新型冠状病毒抗体检测产品的应用与研发。

The combined diagnostic mode of antibody detection and nucleic acid detection plays an important role in the early epidemiological tracing and infection diagnosis of the COVID-19 epidemic.At present,the development of novel coronavirus antibody detection products at home and abroad is mainly based on enzyme-linked immunosorbent assay,immunochromatography,and chemiluminescence immunoassay.Each detection method has its own advantages and disadvantages,and its detection performance is also different.Relevant detection products have come out one after another and are constantly updated and optimized.This article introduces the detection performance and research progress of related detection methods so as to provide references for clinical method selection,research,and development of new antibody detection products and promote the application,research,and development of novel coronavirus antibody detection products.