灸法配合奥司他韦治疗流行性感冒的疗效观察

Therapeutic observation of moxibustion combined with Oseltamivir in treating influenza

目的观察灸法配合口服磷酸奥司他韦胶囊治疗流行性感冒的临床疗效,分析其对患者免疫功能及相关细胞因子水平的影响。方法将150例流行性感冒患者随机分为研究组与对照组,每组75例。对照组采用口服磷酸奥司他韦胶囊治疗,研究组在对照组基础上加用灸法治疗。记录两组治疗期间各项症状(发热、咳嗽、咽喉疼痛)消失时间及总时间,观察治疗前后各项免疫指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)比值)水平及细胞因子[血清C反应蛋白(C-reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)、γ干扰素(interferon-γ,IFN-γ)]水平的变化情况,并比较两组临床疗效及不良反应发生率。结果研究组各项症状(发热、咳嗽、咽喉疼痛)消失时间及总时间均明显短于对照组(P<0.05)。两组治疗后各项细胞因子水平均较同组治疗前显著下降(P<0.05)。研究组治疗前后各项免疫指标差值及细胞因子水平差值与对照组比较,差异均具有统计学意义(P<0.05)。研究组总有效率为93.3%,明显高于对照组的81.3%,差异具有统计学意义(P<0.05)。研究组和对照组治疗期间不良反应发生率分别为9.3%和12.0%,两组比较差异无统计学意义(P>0.05)。结论灸法配合口服磷酸奥司他韦胶囊治疗流行性感冒疗效确切,能有效改善患者临床症状,调节免疫功能,降低血清CRP、IFN-γ、IL-6水平。

Objective To observe the clinical efficacy of moxibustion combined with oral Oseltamivir phosphate capsules in treating influenza and analyze its impact on the patient’s immune function and pertinent cytokine levels.Method A total of 150 patients suffering from influenza were randomly divided into a research group and a control group,each comprising 75 cases.The control group received oral administration of Oseltamivir phosphate capsules for treatment,and the research group received additional moxibustion treatment.The remission time and duration of each symptom(fever,cough,and sore throat)were recorded during the intervention.Before and after the treatment,the immune indicator levels(CD3^(+),CD4^(+),and CD4^(+)/CD8^(+))and cytokine levels[serum C-reactive protein(CRP),interleukin-6(IL-6),and interferon-γ(IFN-γ)]were observed.The clinical efficacy and adverse reaction rate were compared between the two groups.Result The remission time and duration of each symptom(fever,cough,and sore throat)were notably shorter in the research group than in the control group(P<0.05).After the treatment,each cytokine level dropped significantly in both groups(P<0.05).The post-treatment changes in each immune indicator and cytokine levels significantly differed between the two groups(P<0.05).The total effective rate was 93.3%in the research group,higher than 81.3%in the control group,and the difference was statistically significant(P<0.05).The research group had an adverse reaction rate of 9.3%versus 12.0%in the control group,and the difference was statistically insignificant(P>0.05).Conclusion Moxibustion combined with oral Oseltamivir phosphate capsules is effective in treating influenza.This method can improve the patient’s clinical symptoms,regulate immune function,and down-regulate serum CRP,IFN-γ,and IL-6 levels.