胎盘体积结合葡萄糖转运蛋白3对胎儿生长受限的预测价值

Value of placental volume combined with GLUT3 in predicting fetal growth restriction

目的探讨胎盘体积联合血清中葡萄糖转运蛋白3(GLUT3)对胎儿生长受限的预测价值。方法以我院2018年12月—2020年5月行MRI检查的100例胎儿生长受限的孕妇作为观察组,孕检正常的100例孕妇作为对照组。根据MRI检查获取受试者胎盘体积,并检测受试者血清GLUT3的水平;采用logistics回归模型构建胎盘体积与血清GLUT3联合诊断模型,应用ROC曲线下面积(AUC)评判胎盘体积和血清GLUT3独立或两者联合应用对胎儿生长受限的预测价值。结果两组孕妇胎盘体积和血清GLUT3水平比较差异均具有显著性(t=13.380、54.173,P<0.05)。以胎盘体积联合血清GLUT3预测胎儿生长受限的模型为Logit(P)=-0.647×胎盘体积+0.598×GLUT+0.431;胎盘体积联合血清GLUT3预测胎儿生长受限的灵敏度、特异度及AUC均明显高于单个指标(P<0.05)。结论胎盘体积联合血清GLUT3对胎儿生长受限具有一定的预测价值。

Objective To analyze the value of placental volume combined with serum glucose transporter 3(GLUT3)in predicting fetal growth restriction.Methods One hundred pregnant women with fetal growth restriction who underwent MRI examination in our hospital from December 2018 to May 2020 were selected as observation group,and 100 normal pregnant women as control group.The placental volumes of the subjects were measured by MRI examination,and the serum GLUT3 level was mea-sured.The combined diagnosis model of placental volume and serum GLUT3 level was established by logistic regression model.The area under the receiver operating characteristic curve(AUC)was applied to evaluate the value of placental volume and serum GLUT3 level used alone or in combination in predicting fetal growth restriction.Results There were significant differences in placental volume and serum GLUT3 level between the observation group and the control group(t=13.380,54.173,P<0.05).The model of fetal growth restriction predicted by placental volume combined with serum GLUT3 level was Logit(P)=-0.647×placental volume+0.598×GLUT+0.431.The sensitivity,specificity,and AUC of placental volume combined with serum GLUT3 level in predicting fetal growth restriction were significantly higher than those of placental volume or serum GLUT3 level alone(P<0.05).Conclusion Placental volume combined with serum GLUT3 level has a certain predictive value for fetal growth restriction.