大疱性类天疱疮患者嗜酸粒细胞相关指标与疾病严重程度相关性分析

Correlation Between Eosinophil Related Indexes and Disease Severity in Patients with Bullous Pemphigoid

目的分析大疱性类天疱疮(BP)患者外周血及皮损组织中嗜酸粒细胞比例,皮损组织中嗜酸粒细胞趋化因子CCL11表达水平与疾病严重程度之间的相关性。方法本研究纳入65例自2019年1月—2021年1月期间于天津市中医药研究院附属医院皮肤科住院的BP患者,以及24例同一时间段在本院皮肤外科治疗的有医学美容需求的健康人群作为对照组。通过斯皮尔曼相关系数(Spearman correlation coefficient)分析BP患者外周血和皮损组织嗜酸粒细胞、皮损组织嗜酸粒细胞趋化因子CCL11与BP疾病面积指数(BPDAI)评分之间的相关性。结果BP患者外周血和皮损组织嗜酸粒细胞、皮损组织嗜酸粒细胞趋化因子CCL11与BPDAI评分呈正相关(P<0.05);外周血和皮损组织嗜酸粒细胞、皮损组织嗜酸粒细胞趋化因子CCL11均与患者的红斑评分、水疱评分之间有相关性(P<0.05),与患者的损害评分、黏膜评分无相关性;BP患者外周血嗜酸粒细胞与患者的瘙痒评分有相关性(P<0.05)。结论BP患者外周血和皮损组织嗜酸粒细胞、皮损组织嗜酸粒细胞趋化因子CCL11与BPDAI评分之间存在相关性,可在一定程度上反应BP病情严重程度,且可推断其在BP的红斑、水疱形成机制中发挥了一定的作用,此外,外周血嗜酸粒细胞的升高可能与皮肤瘙痒形成机制有关。

Objective In order to analyze the correlation between blood and tissue eosinophil,tissue eosinophil chemokine CCL11 and disease severity in patients with bullous pemphigoid(BP).Methods Sixty-five cases of BP patients hospitalized in the dermatology department of Tianjin academy of traditional Chinese medicine affiliated hospital from January 2019 to January 2021,and 24 healthy people with medical cosmetic needs diagnosed and treated in our hospital at the same time as the control group.Spearman correlation coefficient was used to analyze the correlation between blood and tissue eosinophils,tissue eosinophil chemokine CCL11 and BP disease area index(BPDAI)in patients with BP.Results Blood and tissue eosinophils and tissue eosinophil chemokine CCL11 were positively correlated with BPDAI score in patients with BP(P<0.05).Blood and tissue eosinophils and tissue eosinophil chemokine CCL11 were correlated with erythema score and blister score,but not with lesion score and mucosal score(P<0.05).There was a significant correlation between blood eosinophils and pruritus score in patients with BP(P<0.05).Conclusion There is a correlation between eosinophil and tissue eosinophil chemokine CCL11 and BPDAI score in patients with BP,which can reflect the severity of BP to some extent,and it can be inferred that they play a certain role in the mechanism of erythema and blister formation of BP.In addition,the increase of blood eosinophils may be related to the formation mechanism of skin pruritus.