益肾强督方治疗强直性脊柱炎的临床效果及对患者炎性指标和不良反应的影响

Clinical Effect of Yishen Qiangdu Formula in the Treat ment of Ankylosing Spondylitis and the Impact on Inflammatory Indicators and Adverse Reactions

目的探讨益肾强督方治疗强直性脊柱炎(AS)的临床效果及对患者炎性指标和不良反应的影响。方法将74例AS患者随机分为两组,对照组应用美洛昔康联合柳氮磺吡啶治疗,观察组在对照组基础上采用益肾强督方治疗。比较两组的治疗效果、炎性指标、不良反应发生情况。结果观察组治疗总有效率为97.30%,高于对照组的75.68%(P<0.05)。治疗后,观察组TNF-α、IL-6、IL-10水平低于对照组(P<0.05)。两组不良反应发生发生率比较无统计学差异(P>0.05)。结论益肾强督方联合西药治疗AS患者的临床效果较好,可加速临床症状消退,改善机体炎性反应,减少不良反应。

Objective To explore the clinical effect of Yishen Qiangdu Formula in the treatment of ankylosing spondylitis(AS)and the impact on inflammatory indicators and adverse reactions of patients.Methods 74 AS patients were randomly divided into two groups.The control group was treated with meloxicam and salazopyridine,and the observation group was treated Yishen Qiangdu Formula on the basis of the control group.The treatment effect,inflammatory indicators,and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.30%,higher than 75.68%in the control group(P<0.05).After treatment,the TNF-α,IL-6 and IL-10 levels of the observation group were lower than those of the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Yishen Qiangdu Formula combined with western medicine has better clinical effect in the treatment of AS patients,which can accelerate the disappearance of clinical symptoms of patients,improve body inflammatory responses,and reduce the adverse reactions.