氯吡格雷联合阿司匹林对稳定型心绞痛患者凝血指标及心血管事件发生的影响

Impact of Clopidogrel Combined with Aspirin on Coagulation Indicators and Cardiovascular Events in Patients with Stable Angina

目的探讨氯吡格雷联合阿司匹林对稳定型心绞痛患者凝血指标及心血管事件发生的影响。方法将90例稳定性心绞痛患者随机分为对照组(n=45)和观察组(n=45),对照组口服阿司匹林肠溶片,观察组在对照组基础上采用氯吡格雷治疗。比较两组的临床疗效、凝血指标、心血管事件发生率。结果观察组治疗总有效率为91.1%,明显高于对照组的75.6%(P<0.05)。治疗后,观察组APTT、PT长于对照组,PAR低于对照组(P<0.05)。观察组治疗后6个月的心血管事件发生率为4.4%,低于对照组的17.8%(P<0.05)。结论氯吡格雷联合阿司匹林治疗稳定型心绞痛患者可减少心绞痛发作次数和频率,改善凝血指标,降低心血管事件发生率。

Objective To explore the impact of clopidogrel combined with aspirin on coagulation indicators and cardiovascular events in patients with stable angina.Methods 90 patients with stable angina were randomly divided into control group(n=45)and observation group(n=45).The control group was given oral aspirin enteric coated tablets,while the observation group was treated with clopidogrel on the basis of the control group.The clinical efficacy,coagulation indicators,and incidence of cardiovascular events were compared between the two groups.Results The total effective rate of treatment in the observation group was 91.1%,significantly higher than 75.6%in the control group(P<0.05).After treatment,the APTT and PT of the observation group were longer than those of the control group,and the PAR was lower than that of the control group(P<0.05).The incidence of cardiovascular events in the observation group after 6 months of treatment was 4.4%,lower than 17.8%in the control group(P<0.05).Conclusions Clopidogrel combined with aspirin in the treatment of patients with stable angina can reduce the times and frequency of angina attacks,improve the coagulation indicators,and reduce the incidence of cardiovascular events.