艾灸八髎穴区痧点治疗高龄肾虚血瘀证DOR的临床研究

Study on Moxibustion at Sha Point in Baliao Point Area for DOR of Kidney Deficiency and Blood Stasis Syndrome in Late Childbearing Age Females

目的:比较艾灸八髎穴区痧点结合激素治疗与单纯激素治疗高龄肾虚血瘀证卵巢储备功能减退的疗效差异。方法:将64例卵巢储备功能减退患者随机分为观察组和对照组各32例,观察组采用艾灸八髎穴区痧点结合激素周期治疗,艾灸每次1h,每周治疗3次,经期停用;对照组采用单纯激素周期治疗;两组均1个月经周期为1个疗程,治疗3个疗程结束,观察两组治疗前后卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)、抗苗勒管激素(AMH)、FSH/LH比值、中医证候积分及HAMD、HAMA评分的变化情况。结果:两组治疗后血清FSH、LH、FSH/LH、中医证候积分、HAMD、HAMA均显著降低,血清E2及AMH均显著提高(P<0.05),且观察组治疗后血清FSH、LH、FSH/LH、中医证候积分、HAMD、HAMA评分均低于对照组,而血清E2及AMH高于对照组,差异均有统计学意义(P<0.05)。结论:艾灸八髎穴区痧点联合激素周期疗法治疗高龄肾虚血瘀证卵巢储备功能减退在改善患者性激素、相关症状及情绪方面优于单纯激素周期治疗。

Objective:To compare the therapeutic effects of moxibustion at Sha point in Baliao point area combined with hormone therapy and simple hormone therapy on diminished ovarian reserve(DOR)of Kidney Deficiency and Blood Stasis Syndrome in late childbearing age females.Methods:Sixty-four DOR patients were randomly divided into observation group(n=32)and control group(n=32),the observation group received moxibustion at Sha point in Baliao point area combined with hormone cycle therapy,with moxibustion lasting for 1 hour each time,treated 3 times a week,and stopped during menstruation;while control group received simple hormone cycle therapy.Both groups took one menstrual cycle as one course of treatment,and after three courses of treatment,the changes in follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),anti Mullerian hormone(AMH),FSH/LH ratio,TCM syndrome scores,and HAMD and HAMA scores were observed before and after treatment.Results:After treatment,the serum FSH,LH,FSH/LH,TCM syndrome score,HAMD,HAMA were significantly reduced in both groups,while serum E2 and AMH were significantly increased(P<0.05).Moreover,the serum FSH,LH,FSH/LH,TCM syndrome score,HAMD,HAMA scores in observation group were lower than those in control group,while serum E2 and AMH were higher than those in control group,with statistical significance(P<0.05).Conclusion:The combination of moxibustion at Sha point in Baliao point area and hormone cycle therapy in the treatment of diminished ovarian reserve of kidney deficiency and blood stasis syndrome in late childbearing age females is superior to simple hormone cycle therapy in improving sexual hormones,related symptoms,and emotions.