影响刚地弓形虫组织包囊体内外形成因素的研究进展

Research progress on factors affecting the formation of tissue cysts of Toxoplasma gondii in vitro and in vivo

在刚地弓形虫(Toxoplasma gondii)发育为成熟组织包囊(bradyzoites)和卵囊(sporozoites)的两个时期,传统上需要进行动物试验,这极大地阻碍了对这些阶段的形态和代谢的生物学研究,而此阶段对弓形虫的感染至关重要。因此,在研究组织包囊时利用体外诱导的方法成为研究的重要途径,近年来这方面的研究也取得了一些突破性进展。文章综述了影响组织包囊形成的因素,旨在为弓形虫病的研究、预防和控制提供参考。

Traditionally,animal experiments are needed during the two stages when Toxoplasma gondii develops into mature tissue cysts(bradyzoites)and oocysts(sporozoites),which greatly hinders the biological study of morphology and metabolism in these stages,and the stage is very important for Toxoplasma gondii infection.Therefore,the use of in vitro induction in the study of tissue cysts has become an important way of research,and some breakthroughs have been made in this field in recent years.The article reviews the factors affecting the formation of tissue cysts,aiming to provide a reference for the research,prevention and control of toxoplasmosis.