CRP、PCT、γ-GT联合检测对新生儿高胆红素血症感染的评估价值

Value of combined detection of CRP, PCT, and γ-GT in evaluating neonatal hyperbilirubinemia complicated with infection

目的探究C反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)、γ-谷氨酰转移酶(γ-glutamyltransferase,γ-GT)联合检测对新生儿高胆红素血症感染的预测效能。方法选择高胆红素血症患儿80例,根据预后结局将其分为感染组17例和非感染组63例。比较2组血清中性粒细胞比例、血清淀粉样蛋白A、血小板、CRP、PCT、γ-GT水平。分析高胆红素血症患儿并发感染的影响因素。评估CRP、PCT、γ-GT及联合检测对新生儿高胆红素血症并发感染的预测效能。结果80例高胆红素血症患儿中并发感染17例,发生率为20.99%。感染组患儿血清CRP、PCT、γ-GT水平高于非感染组(P<0.05)。Logistic回归分析结果显示,血清CRP水平升高是高胆红素血症患儿并发感染的危险因素(P<0.05)。ROC分析结果显示,血清CRP、PCT、γ-GT水平单一及联合预测高胆红素血症患儿并发感染的AUC分别为0.713(95%CI:0.601~0.827)、0.707(95%CI:0.602~0.813)、0.673(95%CI:0.551~0.795)、0.802(95%CI:0.713~0.912),联合检测预测效能高于单一检测(P<0.05)。结论血清CRP、PCT、γ-GT水平是新生儿高胆红素血症感染的影响因素,联合检测在新生儿高胆红素血症感染中预测效能较高。

Objective To explore the predictive efficacy of combined detection of C-reactive protein(CRP),procalcitonin(PCT),andγ-glutamyltransferase(γ-GT)for neonatal hyperbilirubinemia complicated with infection.Methods Eighty children with hyperbilirubinemia were selected and divided into the infection group(n=17)and the non-infection group(n=63)according to their prognosis and outcome.The serum neutrophil ratio,serum amyloid A,platelet count,CRP,PCT,andγ-GT levels in the two groups were compared.Factors influencing the incidence of infection in children with hyperbilirubinemia were analyzed.The predictive efficacy of detection of CRP,PCT,γ-GT alone and in combination for neonatal hyperbilirubinemia complicated with infection was evaluated.Results Among the 80 children with hyperbilirubinemia,17 cases(20.99%)were complicated with infection.The serum levels of CRP,PCT,andγ-GT in the infection group were significantly higher than those in the non-infection group(P<0.05).Logistic regression analysis showed that elevated serum levels of CRP was risk factors for infection in children with hyperbilirubinemia(P<0.05).The results of receiver operating characteristic(ROC)analysis showed that the area under the ROC curve(AUC)of serum levels of CRP,PCT,andγ-GT alone or in combination in predicting infection in children with hyperbilirubinemia was 0.713(95%CI:0.601-0.827),0.707(95%CI:0.602-0.813),0.673(95%CI:0.551-0.795),and 0.802(95%CI:0.713-0.912),respectively.Combined detection had a higher predictive efficacy than single detection(P<0.05).Conclusion Serum levels of CRP,PCT,andγ-GT are influential factors in neonatal hyperbilirubinemia complicated with infection,and combined detection exhibits higher predictive efficacy in neonatal hyperbilirubinemia complicated with infection.