独活寄生汤配合温针灸治疗类风湿性关节炎的效果分析

Analysis of the effect of Duhuo Jisheng decoction combined with warm acupuncture in the treatment of rheumatoid arthritis

目的 探究对类风湿性关节炎患者使用独活寄生汤配合温针灸治疗的效果。方法 82例类风湿性关节炎患者作为研究对象,随机分为对照组(n=41)、观察组(n=41)。对照组给予常规治疗,观察组给予独活寄生汤配合温针灸治疗。比较两组患者的临床症状(关节肿胀数目、关节压痛数目、晨僵时间)变化情况,炎症因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)]水平。结果 治疗前,两组关节肿胀数目、关节压痛数目、晨僵时间对比,差异无统计学意义(P>0.05);治疗后,两组关节肿胀数目、关节压痛数目少于治疗前,晨僵时间短于治疗前,且观察组关节肿胀数目(3.12±1.24)个、关节压痛数目(5.12±2.18)个少于对照组的(4.33±2.07)、(7.23±2.88)个,晨僵时间(25.44±9.11)min短于对照组的(32.73±14.82)min,差异显著(P<0.05)。治疗前,两组IL-1、IL-6、TNF-α、CRP对比,差异无统计学意义(P>0.05);治疗后,两组IL-1、IL-6、TNF-α、CRP低于治疗前,且观察组IL-1(32.55±2.76)ng/L、IL-6(16.34±5.11)ng/L、TNF-α(3.83±1.16)pg/ml、CRP(9.18±2.15)mg/L低于对照组的(41.31±3.58)ng/L、(23.06±1.38)ng/L、(7.84±2.52)pg/ml、(18.36±2.41)mg/L,差异显著(P<0.05)。结论 独活寄生汤配合温针灸治疗,可有效改善类风湿性关节炎患者的临床症状,减轻炎症反应,对患者预后改善有积极影响,值得推广。

Objective To explore the effect of Duhuo Jisheng decoction combined with warm acupuncture in the treatment of rheumatoid arthritis.Methods 82 patients with rheumatoid arthritis were studied and randomly divided into a control group(n=41)and an observation group(n=41).The control group was given conventional treatment,and the observation group was given Duhuo Jisheng decoction combined with warm acupuncture for treatment.Both groups were compared in terms of clinical symptoms(number of swollen joints,number of joint tenderness,duration of morning stiffness)and the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-1(IL-1),interleukin-6(IL-6)].Results Before treatment,there was no significant difference in the number of swollen joints,number of joint tenderness and duration of morning stiffness between the two groups(P>0.05).After treatment,the number of swollen joints and number of joint tenderness was less than those before treatment,and the duration of morning stiffness was shorter than that before treatment;the observation group had number of swollen joints of(3.12±1.24)joints and number of joint tenderness of(5.12±2.18)joints,which were less than(4.33±2.07)and(7.23±2.88)joints in the control group;the observation group had shorter duration of morning stiffness of(25.44±9.11)min than(32.73±14.82)min in the control group;the difference was significant(P<0.05).Before treatment,there was no significant difference in IL-1,IL-6,TNF-αand CRP between the two groups(P>0.05).After treatment,IL-1,IL-6,TNF-αand CRP in both groups were lower than those before treatment;the observation group had IL-1 of(32.55±2.76)ng/L,IL-6 of(16.34±5.11)ng/L,TNF-αof(3.83±1.16)pg/ml,and CRP of(9.18±2.15)mg/L,which were lower than(41.31±3.58)ng/L,(23.06±1.38)ng/L,(7.84±2.52)pg/ml,and(18.36±2.41)mg/L in the control group;the difference was significant(P<0.05).Conclusion Duhuo Jisheng decoction combined with warm acupuncture treatment can effectively improve the clinical symptoms of rheumatoid arthritis patients,reduce the inflammatory response,and have a positive impact on the improvement of patients'prognosis,which is worth promoting.