高毒力肺炎克雷伯杆菌致多部位感染的病例分析

Case analysis of multi-site infection caused by hypervirulent Klebsiella pneumoniae

肺炎克雷伯杆菌是一种常见的机会性病原体,基于其高毒力性和易发转移性感染的特征,可引起呼吸系统感染、泌尿系统感染以及肝脓肿等,甚至可以发展成脓毒血症。根据其毒力特征,可分为经典和高毒力肺炎克雷伯杆菌,高毒力肺炎克雷伯杆菌感染常发展迅速,累及全身,病情危重,预后极差,死亡率高。本文选取本院近期收治的3例肺炎克雷伯杆菌感染患者,均有多个器官及组织脓肿,伴有严重的多脏器损害,病情进展迅速,其中1例患者死亡,其余2例患者治疗时间长,迁延多个部位感染,本文总结归纳3例患者特点及治疗方案,对其进行回顾性分析,为临床应对此类感染提供参考,望对此病菌得到重视,早期根据药敏结果针对性用药,缩短患者住院时间,提高临床治疗效果,改善预后。

Klebsiella pneumoniae is a common opportunistic pathogen,based on its high virulent and prone metastatic infection,can cause respiratory system infection,urinary system infection,liver abscess,etc,and even develop into sepsis.According to its virulence characteristics,it can be divided into classical and hypervirulent klebsiella pneumoniae,and hypervirulent Klebsiella pneumoniae infections often develop rapidly,involve the whole body,and are critically ill with poor prognosis and high mortality.This paper selects 3 cases of Klebsiella pneumoniae infection recently admitted to our hospital,all of which have multiple organ and tissue abscesses,accompanied by severe multi-organ damage,rapid progression of the disease,of which 1 patient died,and the remaining 2 patients with a long treatment time,delayed multiple sites of infection.This paper summarizes the characteristics and treatment regimen of the 3 patients and analyzes them retrospectively to provide reference for the clinical response to such infection,hoping that this pathogen will be taken seriously,and that targeted medication will be administered according to the drug sensitivity results at an early stage to shorten the hospitalization time of patients,improve the clinical therapeutic effect,and improve the prognosis.