天麻钩藤饮加减治疗肝亢风动型儿童抽动障碍临床研究

Clinical Study on Modified Tianma Gouteng Decoction for Children with Tic Disorders of Liver Hyperactivity with Stirring Wind Type

目的:观察天麻钩藤饮加减治疗肝亢风动型儿童抽动障碍的临床疗效。方法:选取62例肝亢风动型抽动障碍患儿,按随机数字表法分为对照组和观察组各31例。对照组予以健康宣教、耳穴压豆、盐酸硫必利片治疗,观察组在对照组基础上给予天麻钩藤饮加减治疗。评价2组临床疗效,比较2组治疗前后中医证候积分、耶鲁综合抽动严重程度量表(YGTSS)评分变化,观察不良反应发生情况。结果:观察组总有效率为93.55%,高于对照组77.42%(P<0.05)。治疗后,2组中医证候积分、YGTSS评分较治疗前降低(P<0.05),且观察组中医证候评分、YGTSS评分低于对照组(P<0.05)。观察组不良反应发生率为9.68%,对照组为12.90%,2组比较,差异无统计学意义(P>0.05)。结论:天麻钩藤饮加减能够显著改善肝亢风动型抽动障碍患儿的临床症状,提高临床治疗效果,且安全性较高。

Objective:To observe the clinical effect of modified Tianma Gouteng Decoction on children with tic disorders of liver hyperactivity with stirring wind type.Methods:A total of 62 children with tic disorders of liver hyperactivity with stirring wind type were selected and divided into the control group and the observation group according to the random number table method,with 31 cases in each group.The control group was given health education,auricular point seed-pressing and Tiapride Hydrochloride Tablets for treatment,and the observation group was additionally treated with modified Tianma Gouteng Decotion based on the treatment of the control group.The clinical effects in the two groups were evaluated;the changes in traditional Chinese medicine(TCM)syndrome scores and scores of Yale Global Tic Severity Scale(YGTSS)were compared before and after treatment between the two groups;the incidence of adverse reactions was observed.Results:The total effective rate was 93.55%in the observation group,higher than that of 77.42%in the control group(P<0.05).After treatment,the TCM syndrome scores and YGTSS scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 9.68%in the observation group and 12.90%in the control group,there being no significance in the difference(P>0.05).Conclusion:The therapy of modified Tianma Gouteng Decoction can significantly improve the clinical symptoms of children with tic disorders of liver hyperactivity with stirring wind type,and enhance the clinical effect with good safety.