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心衰一号方联合常规西药治疗气阴两虚兼血瘀型射血分数保留型心力衰竭临床研究

Clinical Study on Xinshuai No.1 Prescription Combined with Conventional Western Medicine for Heart Failure with Preserved Ejection Fraction of Qi and Yin Deficiency Complicated with Blood Stasis Type
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摘要 目的:观察心衰一号方联合常规西药治疗气阴两虚兼血瘀型射血分数保留型心力衰竭的临床疗效。方法:选取气阴两虚兼血瘀型射血分数保留型心力衰竭患者60例,采用随机数字表法分为对照组和观察组各30例,观察组自然脱落3例,对照组脱落4例。对照组给予常规西药治疗,观察组在对照组基础上给予心衰一号方治疗。2组均治疗4周。比较2组治疗前后中医证候积分、6分钟步行距离、纽约心脏病学会(NYHA)心功能分级及血浆N-末端脑钠肽前体(NT-proBNP)水平。结果:治疗后,2组中医证候积分较治疗前降低(P<0.05),且观察组中医证候积分低于对照组(P<0.05)。治疗后,2组6分钟步行距离较治疗前升高(P<0.05),且观察组6分钟步行距离高于对照组(P<0.05)。治疗后,2组心功能分级情况较治疗前改善(P<0.05)。治疗后,2组NT-proBNP水平较治疗前降低(P<0.05),且观察组NT-proBNP水平低于对照组(P<0.05)。结论:心衰一号方联合常规西药治疗气阴两虚兼血瘀型射血分数保留型心力衰竭患者,可以改善患者的临床症状及运动耐量,提高临床疗效。 Objective:To observe the clinical effect of the therapy of Xinshuai No.1 Prescription combined with conventional western medicine on heart failure with preserved ejection fraction of qi and yin deficiency complicated with blood stasis type.Methods:A total of 60 patients with heart failure with preserved ejection fraction of qi and yin deficiency complicated with blood stasis type were selected.They were divided into the control group and the observation group by random number table,with 30 cases in each group.Three cases dropped off naturally in the observation group,and four cases dropped off in the control group.The control group was treated with conventional western medicine,and the observation group was additionally treated with Xinshuai No.1 Prescription based on the treatment of the control group.Both groups were treated for 4 weeks.The traditional Chinese medicine(TCM) syndrome scores,6-minute walking distance,cardiac function grade of New York Heart Association(NYHA),and levels of plasma N-terminal pro-B type natriuretic peptide(NT-proBNP) were compared before and after treatment between the two groups.Results:After treatment,the TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome scores in the observation group were lower than those in the control group(P<0.05).After treatment,the 6-minute walking distance in the two groups was respectively increased when compared with that before treatment(P<0.05),and the 6-minute walking distance in the observation group was higher than that in the control group(P<0.05).After treatment,the cardiac function grade in the two groups was improved when respectively compared with that before treatment(P<0.05).After treatment,the levels of NT-proBNP in the two groups were decreased when compared with those before treatment(P<0.05),and the level of NT-proBNP in the observation group was lower than that in the control group(P<0.05).Conclusion:The therapy of Xinshuai No.1 Prescription combined with conventional western medicine can lessen the clinical symptoms of patients with heart failure with preserved ejection fraction of qi and yin deficiency complicated with blood stasis type,enhance exercise tolerance,and improve clinical effect.
作者 陈栩呈 李建功 林凯旋 CHEN Xucheng;LI Jiangong;LIN Kaixuan(Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510006,China;Zhongshan Hospital of TraditionalChinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Zhongshan Guangdong 528400,China)
出处 《新中医》 CAS 2024年第7期75-79,共5页 New Chinese Medicine
基金 中山市社会公益与基础研究项目(200420123452820)。
关键词 射血分数保留型心力衰竭 气阴两虚兼血瘀型 心衰一号方 中医证候积分 6分钟步行距离 心功能分级 Heart failure with preserved ejection fraction Qi and yin deficiency complicated with blood stasis type Xinshuai No.1 Prescription Traditional Chinese medicine syndrome scores:6-minute walking distance Cardiac function grade
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