新疆地区前列腺导管内癌诊治分析及远期随访研究

Analysis of diagnosis and treatment of intraductal carcinoma of the prostate in Xinjiang and long-term follow-up study

目的研究前列腺导管内癌(IDC-P)临床、病理特征及预后转归。方法通过新疆医科大学第一附属医院泌尿外科前列腺癌临床资料数据库联合新疆医科大学第一附属医院病理科病理资料库,按照纳入及排除标准,自2015年1月至2022年1月筛选出19例病理诊断为IDC-P患者,进行回顾性研究,并与同期前列腺腺癌(Adc-P)患者进行对比研究。结果IDC-P组和Adc-P组在有无骨转移、淋巴结转移、内脏转移、初始总前列腺特异性抗原(TPSA)、碱性磷酸酶差异无统计学意义(P>0.05),在Gleason评分、临床T分期、生存时间差异有统计学意义(P<0.05)。IDC-P组相较Adc-P组具有更高的Gleason评分(P=0.002)和更晚的临床T分期(P=0.041),更短的生存时间[(31±18)个月与(59±19)个月],差异有统计学意义(P<0.001)。结论IDC-P患者具有更高的Gleason评分和更晚的临床T分期特点,且总体预后较差,生存时间较短。

Objective To study the clinical and pathological characteristics and prognostic regression of intraductal carcinoma of the prostate(IDC-P).Methods Through the clinical data database of prostate cancer in the Department of Urology of the First Affiliated Hospital of Xinjiang Medical University in conjunction with the pathological database of the Department of Pathology of the First Affiliated Hospital of Xinjiang Medical University,19 patients with pathological diagnosis of IDC-P were screened according to the inclusion and exclusion criteria from January 2015 to January 2022 for a retrospective study and compared with the patients with adenocarcinoma of the prostate(Adc-P)during the same period for a comparative study.Results There was no statistically significant difference between IDC-P and Adc-P groups in the presence or absence of bone metastasis,lymph node metastasis,visceral metastasis,initial tatal prostate-specific antigen(TPSA),alkaline phosphatase(P>0.05),and there was a statistically significant difference in the Gleason score,clinical T-stage,and survival time(P<0.05).The IDC-P group had a higher Gleason score compared with the Adc-P group(P=0.002)and later clinical T-stage(P=0.041),and shorter survival time[(31±18)months vs(59±19)months](P<0.001).Conclusion Patients with IDC-P were characterized by higher Gleason scores and later clinical T-stages and had a poorer overall prognosis and shorter survival time.