住院老年病人衰弱综合征与胰岛素样生长因子-1的相关性研究

Correlation between insulin-like growth factor-1 and frailty syndrome in hospitalized elderly patients

目的 研究胰岛素样生长因子-1(insulin-like growth factor-1, IGF-1)水平与住院老年病人衰弱综合征的相关性。方法 选取2021年3—8月在我科住院的201例老年病人为研究对象,依据衰弱指数(FI)水平将其分为无衰弱组、衰弱前期组、衰弱组,收集病人营养状况、生活能力、合并症等临床资料,检测IGF-1水平,分析衰弱综合征的相关因素。结果 201例病人中,无衰弱的病人占7.46%(15例)、衰弱前期占44.28%(89例)、衰弱占48.26%(97例),3组病人年龄、Barthel指数、营养风险、服药种类、冠心病比例、IGF-1水平比较,差异均有统计学意义(P<0.05);多因素有序Logistic回归分析显示,Barthel指数下降是衰弱的危险因素(OR=1.859, 95%CI:1.103~3.134),IGF-1水平升高是衰弱的保护因素(OR=0.984, 95%CI:0.976~0.992)。偏相关分析显示,IGF-1水平与FI呈负相关(r=-0.241,P<0.05)。结论 住院老年病人衰弱综合征发生率高,Barthel指数下降是衰弱的危险因素,IGF-1水平升高是衰弱的保护因素。

Objective To investigate the correlation between insulin-like growth factor-1(IGF-1)and frailty syndrome in the hospitalized elderly patients.Methods A total of 201 elderly patients hospitalized in Department of Geriatrics from March to August 2021 were enrolled in this study.According to frailty index(FI),all patients were divided into non-frailty group,pre-frailty group and frailty group.The clinical data such as nutritional status,living ability and comorbidities were collected and the level of IGF-1 was detected,and all parameters were compared among the three groups.The influencinig factors of frailty syndrome were analyzed.Results The proportion of non-frailty,pre-frailty and frailty in 201 cases was 7.46%(15 cases),44.28%(89 cases)and 48.26%(97 cases),respectively.The differences in age,Barthel index,nutritional risk,types of medication,proportion of coronary heart disease and the level of IGF-1 were statistically significant among the three groups(P<0.05).Multiple ordered Logistic regression analysis showed that the decline of Barthel index was a risk factor for frailty(OR=1.859,95%CI:1.103-3.134),and the high level of IGF-1 was a protective factor for frailty(OR=0.984,95%CI:0.976-0.992).Partial correlation analysis showed that IGF-1 was negatively correlated with FI(r=-0.241,P<0.05).Conclusions The incidence of frailty is high in hospitalized elderly patients.The decrease of Barthel index is a risk factor for frailty,and the increase of IGF-1 is a protective factor for frailty.