抗甲状腺球蛋白抗体与分化型甲状腺癌关系研究现状

Research status of the relationship between anti-thyroglobulin antibodies and differentiated thyroid cancer

甲状腺癌作为目前发病率上升最快、甲状腺外科最常见的内分泌恶性肿瘤而备受关注, 手术切除联合131I核素治疗、促甲状腺激素抑制治疗是其主要治疗方法。分化型甲状腺癌是甲状腺癌中最常见的类型。甲状腺球蛋白是分化型甲状腺癌术后随访最常用的肿瘤标志物。然而, 甲状腺球蛋白抗体(thyroglobulin antibodies, TgAb)的存在会影响甲状腺球蛋白的检测, 因此, 在甲状腺癌患者的随访过程中, TgAb的检测显得尤为重要。本综述将探讨TgAb的检测在分化型甲状腺癌患者的诊断和随访中的临床应用, 为临床实践提供有益的参考。

Thyroid cancer has attracted much attention as the fastest rising incidence and the most common endocrine malignant tumor in thyroid surgery.At present,treatment methods primarily include surgical resection+131I radionuclide therapy+thyroid stimulating hormone suppression therapy.Differentiated thyroid cancer is the most common type of thyroid cancer.Thyroglobulin is the most commonly used tumor marker in postoperative follow-up of differentiated thyroid cancer.However,thyroglobulin antibodies(TgAb)can affect the detection of thyroglobulin.Therefore,the detection of TgAb is particularly important in the follow-up of patients with thyroid cancer.This review will focus on the clinical application of TgAb detection in the diagnosis and follow-up of patients with differentiated thyroid cancer,and provide a useful reference for clinical practice.