头颈部鳞状细胞癌中USP10的表达及其预后价值

Expression and Prognostic Value of USP10 in Head and Neck Squamous Cell Carcinoma

目的:研究头颈鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)组织中泛素-特异性蛋白酶10(ubiquitin-specific peptidase 10,USP10)的表达情况并探讨其预后价值。方法:通过UALCAN网站分析HNSCC中USP10 mRNA和蛋白质的表达水平,采用免疫组织化学法检测70例HNSCC组织和30例正常组织中USP10蛋白的表达,分析HNSCC中USP10的表达与临床特征和预后的关系。结果:HNSCC组织中USP10表达上调(P<0.05),且USP10的表达与分化程度相关(P<0.05)。Kaplan-Meier分析结果显示,USP10高表达组生存时间短于低表达组(P<0.05)。Cox回归分析结果显示,淋巴转移和USP10高表达是HNSCC患者预后不良的独立危险因素(P<0.05)。结论:HNSCC中USP10表达升高,USP10可作为HNSCC的预后标志物。

Objective:To study the expression of USP10 and its prognostic value in head and neck squamous cell carcinoma(HNSCC).Methods:The UALCAN website was utilized to analyze the expression of USP10 mRNA and protein in HNSCC.The protein expression of USP10 was detected by immunohistochemical method in 70 HNSCC tissues and 30 normal tissues.The relationship between USP10 in HNSCC and clinical features and prognosis was analyzed.Results:The expression of USP10 was increased in HNSCC tissues(P<0.05),and the expression of USP10 was related to the degree of differentiation(P<0.05).Kaplan-Meier analysis results showed that the high USP10 expression group had a shorter survival time than the low expression group(P<0.05).Cox regression analysis results showed that lymphatic metastasis and high USP10 expression was independent risk factors for poor prognosis in HNSCC patients(P<0.05).Conclusion:The expression of USP10 is increased in HNSCC.USP10 may be a prognostic marker for HNSCC.