摘要
Nanocarriers have therapeutic potential to facilitate drug delivery,including biological agents,smallmolecule drugs,and nucleic acids.However,their efficiency is limited by several factors;among which,endosomal/lysosomal degradation after endocytosis is the most important.This review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport mechanisms.These strategies include promoting endosomal/lysosomal escape,using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/lysosomes.On the basis of the findings of this review,we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.
出处
《Research》
SCIE
EI
CSCD
2024年第1期315-337,共23页
研究（英文）
基金
the Fundamental Research Funds for the National Natural Science Foundation(nos.82204322 and 82104480)
the Central Public Welfare Research Institutes(grant nos.:ZZ16-ND-10-05,ZZ16-ND10-13,ZZ16-ND-10-17,ZZ16-ND-10-19,ZZ14-YQ-050,ZZ14-YQ-055,ZZ14-YQ-059,ZZ14-YQ-060,and ZZ16-YQ-046)
the Young Elite Scientists Sponsorship Program by CACM(2021QNRC2B29).
