神经生长因子局部注射联合根管治疗术治疗牙髓炎的临床研究

Clinical effect of local injection of nerve growth factor and root canal therapy in treating pulpitis

目的研究神经生长因子(NGF)局部注射联合根管治疗术治疗牙髓炎的临床效果。方法92例牙髓炎患者分成观察组及对照组各46例(46颗牙),患者均实施根管治疗,对照组予以甲硝唑治疗,观察组在此基础上另实施NGF局部注射,两组均治疗10d,比较两组疗效、牙周指标以及不良反应。结果观察组总有效率高于对照组(P<0.05)。治疗后两组的牙龈指数(GI)、牙周袋深度(PD)及龈沟出血指数(SBI)评分均低于治疗前,且观察组低于对照组(P<0.05)。观察组不良反应的总发生率低于对照组(P<0.05)。结论NGF局部注射以及根管治疗术联合对牙髓炎患者的临床效果较好,能够有效改善患者的牙周症状,安全性也较高。

【Objective】To study the clinical effect of local injection of nerve growth factor(NGF)and root canal therapy in treating pulpitis.【Methods】Ninety-two cases of pulpitis patients were divided into observation group and control group with 46 cases(46 teeth)in each group,patients were given root canal therapy.The control group was given metronidazole tablets,the observation group was given NGF local injection on the basis of control group,both groups were treated for 10 d.The efficacy,periodontal index,and adverse reactions between the two groups were compared.【Results】The total response rate in the observation group was higher than the control group(P<0.05).The gingival index(GI),periodontal pocket depth(PD)and sulcus bleeding index(SBI)scores were significantly lower than before treatment,and the observation group was lower than the control group(P<0.05).The overall incidence of adverse effects in the observation group was significantly lower than the control group(P<0.05).【Conclusion】The combination of NGF local injection and root canal therapy has a good clinical effect on patients with pulpitis,can effectively improve the periodontal symptoms,and has a high safety.