瑞舒伐他汀配合替罗非班治疗对急性缺血性脑卒中患者神经功能、血清炎症因子水平的影响

Effects of Rosuvastatin Combined with Tirofiban on Neurological Function and Serum Inflammatory Factor Levels in Patients with Acute Ischemic Stroke

目的分析瑞舒伐他汀与替罗非班在急性缺血性脑卒中(Acute Ischemic Stroke,AIS)患者中的应用效果。方法回顾性选取兰陵县人民医院于2019年9月—2022年12月收治的90例AIS患者的临床资料,按治疗方式不同分为对照组和观察组,各45例。两组患者均给予降颅内压、吸氧、保护脑神经等常规治疗,对照组在常规治疗基础上给予替罗非班注射液治疗;观察组在对照组基础上给予瑞舒伐他汀钙片口服治疗。对比两组患者炎症因子水平、临床效果、神经功能、血脂及不良反应总发生率。结果观察组治疗总有效率、白细胞介素-10、Barthel指数、高密度脂蛋白胆固醇高于对照组,美国卫生部卒中评分、白细胞介素-6、肿瘤坏死因子-α、超敏C反应蛋白、三酰甘油、总胆固醇、低密度脂蛋白胆固醇水平低于对照组,差异有统计学意义(P均<0.05);两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论瑞舒伐他汀联合替罗非班治疗AIS能够促进患者神经功能改善,调节炎症因子水平及血脂水平,且具有较高的安全性。

Objective To analyze the effects of rosuvastatin and tirofiban on patients with acute ischemic stroke(AIS).Methods Clinical data of 90 AIS patients admitted to Lanling County People's Hospital from September 2019 to December 2022 were retrospectively selected and divided into control group and observation group according to different treatment methods,with 45 cases in each group.Both groups were given conventional treatment to reduce intracranial pressure,oxygen inhalation and cerebral nerve protection,while the control group was given intravenous tirofiban injection on the basis of conventional treatment.Observation group was given rosuvastatin calcium tablet oral therapy on the basis of control group.Inflammatory factors levels,clinical effects,neurological function,blood lipids and total incidence of adverse reactions were compared between the two groups.Results The total effective rate,interleukin-10,Barthel index and high density lipoprotein cholesterol in observation group were higher than those in control group,while the score of National Institute Health Stork Scale,interleukin-6,tumor necrosis factor-α,hypersensitive C�reactive protein,triacylglycerol,total cholesterol and low density lipoprotein cholesterol levels in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Rosuvastatin combined with tirofiban in the treatment of AIS can improve the neurological function of patients,regulate the levels of inflammatory factors and blood lipids,and has a high safety.