肺康复联合无创通气治疗在重度慢性阻塞性肺疾病中的应用效果分析

Application Effect of Lung Rehabilitation Combined with Non-invasive Ventilation in Severe COPD

目的分析肺康复联合无创通气治疗在重度慢性阻塞性肺疾病中的应用效果。方法选取2020年10月—2023年11月济南市第一人民医院呼吸内科收治的76例重度慢性阻塞性肺疾病患者为研究对象,用随机抽签法分为对照组(无创通气治疗)、观察组(肺康复联合无创通气治疗),各38例。对比两组患者肺功能、运动耐力、炎症因子水平、血气指标和生存质量评分。结果治疗前,两组肺功能、运动耐力、症状评分、炎症因子水平、血气指标、生存质量评分对比,差异无统计学意义(P均>0.05)。治疗后,观察组第1秒用力呼气容积、FEV1%预测值、用力肺活量、第1秒用力呼气容积与用力肺活量的比值、6 min步行试验结果均优于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组症状评分、炎症因子水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组动脉血氧分压高于对照组,动脉二氧化碳分压低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组生存质量各维度评分均高于对照组,差异有统计学意义(P均<0.05)。结论重度慢性阻塞性肺疾病患者开展肺康复联合无创通气治疗可促进患者肺功能康复,缓解患者症状,提升患者的生存质量。

Objective To analyze the application effect of lung rehabilitation combined with non-invasive ventilation in severe chronic obstructive pulmonary disease(COPD).Methods From October 2020 to November 2023,76 patients with severe COPD admitted to the Respiratory Medicine Department of Jinan First People's Hospital were selected as the study objects and were divided into control group(non-invasive ventilation treatment)and observation group(lung rehabilitation combined with non-invasive ventilation treatment)by random drawing method,with 38 cases in each group.Lung function,exercise endurance,symptom scores,inflammatory factor level,blood gas index and quality of survival scores were compared between the two groups.Results There was no significant difference in lung function,exercise endurance,symptom scores,inflammatory factor level,blood gas index and quality of survival scores between the two groups before treatment(all P>0.05).After treatment,forced expiratory volume in the first second(FEV1),FEV1%pred,forced vital capacity(FVC),FEV1/FVC and the result of 6 min walking test of the observation group were better than those of the control group,the differences were statistically significant(all P<0.05).After treatment,the symptom scores,inflammatory factor level of the observation group were lower than those of the control group,the differences were statistically significant(all P<0.05).After treatment,the partial pressure of oxygen in artery of the ob servation group was higher than that of the control group,the partial pressure of carbon dioxide in artery was lower than that of the control group,the differences were statistically significant(both P<0.05).After treatment,the quality of survival scores of the observation group were higher than those of the control group,the differences were statistically significant(all P<0.05).Conclusion Lung rehabilitation combined with non-invasive ventilation was carried out in pa tients with severe COPD can promote the rehabilitation of lung function.It can also relieve their symptoms and im prove the quality of life of patients.