分析硫酸镁分别与拉贝洛尔及硝苯地平联合治疗妊高症子痫前期的价值

Value of Magnesium Sulfate Combined with Labetalol and Nifedipine in the Treatment of Pregnancy-induced Hypertension Preeclampsia

目的分析硫酸镁分别结合拉贝洛尔、硝苯地平治疗对妊娠高血压疾病(简称“妊高症”)子痫前期的影响。方法选取2021年10月—2023年10月济宁市兖州区人民医院收治的60例妊高症子痫前期患者为研究对象,采用奇偶数法随机分为比照组、实践组,各30例。比照组行硫酸镁+硝苯地平治疗,实践组行硫酸镁+拉贝洛尔治疗。比较两组患者血压、血管内皮功能、临床疗效、不良结局发生情况。结果用药后,两组血压均降低,且实践组低于比照组,差异有统计学意义(P均<0.05)。用药后,实践组一氧化氮(Nitrogen Monoxide,NO)高于比照组,内皮素-1(Endothelin-1,ET-1)低于比照组,差异有统计学意义(P均<0.05)。实践组治疗总有效率高于比照组,差异有统计学意义(P<0.05)。实践组不良结局总发生率低于比照组(3.33%vs 20.00%),差异有统计学意义(χ^(2)=4.043,P=0.044)。结论硫酸镁+拉贝洛尔治疗妊高症子痫前期效果更为显著,可恢复血管内皮功能,降低血压,减少不良结局,改善妊高症子痫前期预后。

Objective To analyze the effects of magnesium sulfate combined with labetalol and nifedipine on pregnancy-induced hypertension preeclampsia.Methods A total of 60 patients with pregnancy-induced hypertension preeclampsia in Yanzhou District People's Hospital of Jining City from October 2021 to October 2023 were selected as the study objects and were divided into the comparison group and the practice group according to odd and even number method,with 30 cases in each group.The comparison group was treated with magnesium sulfate+nifedipine,and the practice group was treated with magnesium sulfate+labetalol.Blood pressure,vascular endothelial function,clinical efficacy,adverse outcomes were compared between the two groups.Results The blood pressure in the two groups were decreased after treatment,and the blood pressure in the practice group was lower than those in the com parison group,the differences were statistically significant(all P<0.05).After treatment,Nitrogen Monoxide(NO)in practice group was higher than that in comparison group,and Endothelin-1(ET-1)in practice group was lower than that in comparison group,the differences were statistically significant(all P<0.05).The total effective rate in practice group was higher than that in comparison group,the difference was statistically significant(P<0.05).The incidence of adverse outcomes in the practice group were lower than that in the comparison group(3.33%vs 20.00%),the differ ence was statistically significant(χ^(2)=4.043,P=0.044).Conclusion Magnesium sulfate+labetalol can achieve a more significant effect,which can restore vascular endothelial function,reduce blood pressure,reduce adverse outcomes,and improve the prognosis of pregnancy-induced hypertension preeclampsia.