2021年深圳市南山区287名大学新生百日咳和白喉及破伤风抗体水平调查

Survey of antibody levels of pertussis,diphtheria and tetanus in 287 college freshmen in Nanshan district,Shenzhen in 2021

目的了解深圳市南山区大学新生百日咳、白喉、破伤风IgG抗体水平。方法于2021年9月,以深圳市南山区287名大学新生作为调查对象,采用酶联免疫吸附试验法检测血清中百日咳、白喉、破伤风IgG抗体水平,比较不同特征大学新生各抗体水平差异。结果大学新生百日咳的抗体几何平均浓度(GMC)和阳性率分别为14.642(13.073~16.399)IU/mL、20.56%(59名)。大学新生白喉的抗体GMC、阳性率和保护率分别为0.098(0.086~0.111)IU/mL、98.95%(284名)、46.69%(134名)。大学新生破伤风的抗体GMC、阳性率和保护率分别为0.121(0.106~0.139)IU/mL、100.00%(287名)、54.70%(157名)。不同分组大学新生的百白破抗体浓度差异均无统计学意义(P均>0.05)。结论深圳市南山区大学新生人群百日咳抗体阳性率较高,提示近期百日咳感染比例较高,需加强对此群体的百日咳的监测;白喉、破伤风抗体阳性率较高,而保护率较低,可能需要进一步的疫苗接种政策。

Objective To investigate the levels of pertussis,diphtheria,and tetanus(DPT)IgG antibodies in college freshmen in Nanshan district,Shenzhen.Methods In September 2021,287 college freshmen in Nanshan district,Shenzhen were selected as the survey subjects.The serum levels of pertussis,diphtheria and tetanus IgG antibodies were detected by enzyme⁃linked immunosorbent assay,and the differences in the antibody levels of college freshmen with different characteristics were compared.Results The antibody geometric mean concentrations(GMC)and positive rates of pertussis antibody in college freshmen were 14.642(13.073-16.399)IU/mL and 20.56%(59 cases),respectively.The antibody GMC,positive rate and protection rate of diphtheria in college freshmen were 0.098(0.086-0.111)IU/mL,98.95%(284 cases)and 46.69%(134 cases),respectively.The antibody GMC,positive rate and protection rate of tetanus in college freshmen were 0.121(0.106-0.139)IU/mL,100.00%(287 cases)and 54.70%(157 cases)respectively.There were not statistically significant differences in the concentration of DPT antibody among freshmen in different groups(all P>0.05).Conclusions The positive rate of pertussis antibody in college freshmen in Nanshan district of Shenzhen city was high,which suggested that the proportion of pertussis infection was high in the near future.The monitoring of pertussis in this population should be strengthened.Vaccination policies should also be implemented for the high positive rates and low protective rate of diphtheria and tetanus antibodies.