摘要
Stimulator of interferon genes(STING),also known as MITA,ERIS,MPYS or TMEM173,is a key player in innate immunity,specifically in the typeⅠinterferon response[1-3].It is also involved in a range of non-canonical biological functions,including autophagy,cellular metabolism,translation,and DNA repair,and has implications in many diseases[4-9].After activation by its ligands,STING translocates from endoplasmic reticulum(ER),via ERGIC,Golgi apparatus and endosomes,finally to lysosomes for degradation[4-9].However,the mechanisms by which STING is delivered to lysosomes and whether this delivery process regulates STING activity remain elusive.
作者
赵远
周晨暄
田文敏
陈杨
赵冲冲
栗妍
王世宣
荣岳光
Yuan Zhao;Chenxuan Zhou;Wenmin Tian;Yang Chen;Chongchong Zhao;Yan Li;Shixuan Wang;Yueguang Rong(School of Basic Medicine,Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease,Huazhong University of Science and Technology,Wuhan 430030,China;Center for Precision Medicine Multi-Omics Research,Peking University Health Science Center,Peking University,Beijing 100191,China;School of Basic Medical Sciences,Peking University Health Science Center,Peking University,Beijing 100083,China;The State Key Laboratory of Membrane Biology,Tsinghua University-Peking University Joint Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing 100084,China;The HIT Center for Life Sciences,Harbin Institute of Technology,Harbin 150080,China;Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Cell Architecture Research Center,Huazhong University of Science and Technology,Wuhan 430030,China)
基金
supported by the National Natural Science Foundation of China(92254302,91854116,31771529 and 32170685)
the Fundamental Research Funds for the Central Universities(5003510089 and 2023BR028)。
