胰腺癌放疗的研究进展

Research Progress of Radiotherapy on Pancreatic Cancer

近年胰腺癌的治疗方式仍以手术为主,但是对于无法手术切除或临界可以切除的患者,放疗逐渐展现出其重要的补充作用。特别是在提高局部控制率和减少复发方面,新辅助放疗扮演了重要角色。目前对处于不同阶段的胰腺癌,如局部晚期和晚期胰腺癌,正在进行相应的放疗研究。同时,关于放疗剂量、分割模式、靶区勾画已逐步形成共识,且针对质子和重离子放疗,放疗与免疫治疗、放疗与靶向治疗的结合等具体问题,也进行了诸多研究。未来需要有更多的研究针对放疗进行深入探索,以期达到个体化、精准化治疗,不断提高疗效。

In recent years,surgery is still the main treatment for pancreatic cancer,but for unresectable or borderline resectable patients,radiotherapy has gradually shown its important complementary role.In particular,neoadjuvant radiotherapy plays an important role in improving local control and reducing recurrence.Corresponding radiotherapy studies are currently being conducted for pancreatic cancer at different stages,such as locally advanced and advanced pancreatic cancer.At the same time,a consensus has been gradually formed on the dose,fractionation mode,and target volume delineation of radiotherapy.In addition,many studies have been carried out on specific issues such as proton and heavy ion radiotherapy,radiotherapy and immunotherapy,and the combination of radiotherapy and targeted therapy.In the future,more studies are needed to explore radiotherapy in order to achieve individualized and precise treatment,and continuously improve the efficacy.