草灵丹加减联合温经浴袋改善恶性肿瘤患者高凝状态临床观察

Clinical efficacy of modified Caoling pill combined with warming meridian bath bag on improving hypercoagulable state in patients with malignant tumors

目的:探究草灵丹加减联合温经浴袋改善恶性肿瘤患者高凝状态的临床疗效。方法:选取恶性肿瘤高凝状态患者60例,按照随机对照法分为对照组和试验组,各30例。对照组采用肿瘤常规治疗加注射依诺肝素钠,试验组采用肿瘤常规治疗、注射依诺肝素钠、草灵丹加减、温经浴袋。对比两组治疗前后中医证候积分、凝血指标[血小板计数(PLT)、纤维蛋白原(FIB)、D-二聚体(D-D)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]、静脉血栓栓塞症(VTE)风险评估及生存质量[卡氏功能状态量表(KPS)],分析两组治疗过程中不良反应发生情况。结果:治疗后两组凝血指标PT、APTT及KPS较治疗前显著升高,且试验组显著高于对照组(P<0.05);治疗后两组各中医证候积分、凝血指标PLT、FIB、D-D、VTE风险积分降低,且试验组显著低于对照组(P<0.05),试验组不良反应发生率为6.67%,与对照组13.33%比较无统计学差异(P>0.05)。结论:草灵丹加减联合温经浴袋治疗能缓解恶性肿瘤患者高凝状态,改善凝血功能,并降低VTE发生风险,对提高生存质量有积极意义。

Objective:To explore the clinical efficacy of modified Caoling pill combined with warming meridian bath bag on improving hypercoagulable state in patients with malignant tumors.Methods:60 patients with malignant tumors in hypercoagulable state were divided into control group and trial group according to the randomized control method,with 30 cases in each group.The control group was treated with enoxaparin sodium on the basis of conventional tumor treatment,and the trial group was treated with modified Caoling pill combined with warming meridian bath bag on the basis of the control group.TCM syndromes scores,coagulation indicators[platelet count(PLT),fibrinogen(FIB),D-dimer(D-D),prothrombin time(PT),activated partial thromboplastin time(APTT)],venous thromboembolism(VTE)risk assessment and quality of life[Karnofsky Performance Scale(KPS)]were compared between the two groups after treatment,and the adverse reactions were analyzed in the two groups during treatment.Results:After treatment,the coagulation indicators of PT and APTT and KPS score in the two groups were significantly enhanced compared to before treatment,and the above indicators in trial group were significantly higher than those in control group(P<0.05).After treatment,TCM syndromes scores,coagulation indicators of PLT,FIB and D-D,VTE risk score in both groups were significantly reduced compared with those before treatment,and the indicators were significantly lower in trial group than those in control group(P<0.05).The incidence of adverse reactions in trial group was 6.67%,which was not significantly different from 13.33%in control group(P>0.05).Conclusion:Modified Caoling pill combined with warming meridian bath bag can alleviate the hypercoagulable state,improve the coagulation function and blood viscosity,relieve the cancer-related fatigue and reduce the risk of VTE in patients with malignant tumors,and it has positive significance for improving the quality of life.