血清学指标预测气管支气管恶性病变狭窄患者发生再狭窄的临床意义

Clinical Significance of Serological Indexes in Predicting Restenosis in Patients with Malignant Tracheobronchial Stenosis

目的分析血清学指标(癌胚抗原、C反应蛋白和低氧诱导因子-1α)预测气管支气管恶性病变狭窄患者发生再狭窄的临床意义。方法选取福建省建瓯市立医院2020年10月—2022年10月收治的80例气管支气管恶性病变狭窄患者进行回顾性研究,术后随访90 d,根据术后有无再狭窄分组,对比两组一般资料,检测癌胚抗原、C反应蛋白和低氧诱导因子-1α水平,对癌胚抗原、C反应蛋白和低氧诱导因子-1α与术后再狭窄的相关性分析,评估血清指标联合检测对再狭窄的预测价值。结果80例患者中术后发生再狭窄24例,未发生狭窄56例;再狭窄组患者癌胚抗原水平、C反应蛋白水平和低氧诱导因子-1α水平高于未狭窄组(P<0.05);Pearson相关系数分析结果显示:癌胚抗原、C反应蛋白和低氧诱导因子-1α与术后再狭窄正相关(P<0.05);受试者工作特征(ROC)曲线分析结果显示,联合癌胚抗原、C反应蛋白和低氧诱导因子-1α检测用于术后再狭窄的预测价值更高。结论联合检测癌胚抗原、C反应蛋白和低氧诱导因子-1α水平可准确预测气管支气管恶性病变狭窄术后再狭窄的发生。

Objective To analyze the clinical significance of serologic indexes(carcinoembryonic antigen,C-reactive protein and hypoxicinducible factor-1α)in predicting restenosis in patients with malignant tracheobronchial stenosis.Methods A retrospective study was conducted on 80 patients with malignant tracheobronchial stenosis admitted to Jian'ou Municipal Hospital in Fujian Province from October 2020 to October 2022.After 90 days of postoperative follow-up,the general data of the two groups were compared according to whether there was restenosis after surgery,and the levels of carcinogerm antigen,C-reactive protein and hypoxic-inducible factor-1αwere detected.The correlation between the three indexes and postoperative restenosis was analyzed to evaluate the predictive value of serum indexes combined detection for restenosis.Results Among the 80 patients,24 cases were restenosis and 56 cases were unstenosis.The levels of carcinoembryonic antigen,C-reactive protein and hypoxia inducible factor-1αin restenosis group were higher than those in non-stenosis group(P<0.05).Pearson correlation coefficient analysis showed that carcinoembryonic antigen,C-reactive protein,and hypoxia inducible factor-1αhas a positive correlation with postoperative restenosis(P<0.05).Receiver operating characteristic(ROC)curve shows a combination of carcinoembryonic antigen,C-reactive protein,and hypoxia inducible factor-1αthe predictive value of detection for postoperative restenosis was higher.Conclusions Joint detection of carcinoembryonic antigen,C-reactive protein,and hypoxia inducible factor-1αLevel can accurately predict the occurrence of postoperative restenosis in patients with malignant stenosis of the trachea and bronchi.