HBGH患者血清CGN、SDC-1水平与病情及疾病转归的关系

Serum levels of CGN and SDC-1 in patients with HBGH and their relationship with disease and disease outcome

目的 探讨血清扣带蛋白(CGN)、多配体聚糖-1(SDC-1)水平与高血压性基底节脑出血(HBGH)患者病情及疾病转归的关系。方法 选取2019年2月至2022年2月连云港市第二人民医院(下称该院)收治的123例HBGH患者为研究对象,另选择该院同期行健康体检的体检健康者120例为健康组。检测两组纳入对象血清CGN、SDC-1表达水平。根据疾病转归情况将患者分为好转组92例,恶化组31例。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析血清CGN、SDC-1表达水平对HBGH患者疾病转归的预测价值。结果 重度组血清CGN、SDC-1表达水平均高于中度组、轻度组,且中度组血清CGN、SDC-1表达水平均高于轻度组,差异有统计学意义(P<0.05),3组HBGH患者血清CGN、SDC-1表达水平均高于健康组,差异有统计学意义(P<0.05)。恶化组血清CGN、SDC-1表达水平高于好转组,差异有统计学意义(P<0.05)。血清CGN、SDC-1预测HBGH患者疾病转归的AUC分别为0.742(95%CI:0.792~0.697)、0.861(95%CI:0.906~0.910),两者联合预测的AUC为0.917(95%CI:0.962~0.870)。恶化组出血量、破入脑室情况明显高于好转组,入院格拉斯哥昏迷量表(GCS)评分低于好转组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,血清CGN≥51.63 pg/mL(OR=3.815)、血清SDC-1≥450.67μg/L(OR=4.230)、入院GCS评分≤8分(OR=5.333)是HBGH患者疾病转归的影响因素(P<0.05)。结论 血清CGN、SDC-1表达水平升高与HBGH患者病情加重、疾病转归恶化密切相关,二者对HBGH患者疾病转归具有一定预测价值。

Objective To explore the relationship between the expression levels of serum cingulate protein(CGN)and polyligand glycan 1(SDC-1)and the disease condition and outcome of hypertensive basal ganglia hemorrhage(HBGH).Methods A total of 123 patients with HBGH admitted to the Second People′s Hospital of Lianyungang from February 2019 to February 2022 were selected as the study objects,and 120 healthy volunteers who underwent physical examination in the hospital during the same period were selected as the health group.Serum CGN and SDC-1 expression levels were detected in the two groups.According to the disease outcome,the patients were divided into the improved group(92 cases)and the deteriorated group(31 cases).Receiver operating characteristic(ROC)curve and the area under the curve(AUC)were used to analyze the predictive value of serum CGN and SDC-1 expression levels on the disease outcome of patients with HBGH.Results Serum CGN and SDC-1 expression levels in the severe group were higher than those in the moderate group and the mild group,and serum CGN and SDC-1 levels in the moderate group were higher than those in the mild group,and the differences were statistically significant(P<0.05).Serum CGN and SDC-1 expression levels in HBGH patients in three groups were higher than those in health group,and the differences were statistically significant(P<0.05).Serum CGN and SDC-1 expression levels in the deteriorated group were higher than those in the improved group,and the differences were statistically significant(P<0.05).The AUC of serum CGN and SDC-1 for predicting the disease outcome of HBGH patients was 0.742(95%CI:0.792-0.697)and 0.861(95%CI:0.906-0.910),respectively,and the AUC of the combination of the two was 0.917(95%CI:0.962-0.870).The amount of blood loss and ventricular rupture in the deteriorated group were higher than those in the improved group,and the Glasgow Coma Scale(GCS)score on admission was lower than that in the improved group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that serum CGN≥51.63 pg/mL(OR=3.815),serum SDC-1≥450.67μg/L(OR=4.230)and GCS score≤8(OR=5.333)were the influencing factors for disease outcome of HBGH patients(P<0.05).Conclusion The increased expression levels of serum CGN and SDC-1 are closely related to the disease aggravation and the deterioration of the disease outcome in patients with HBGH,and they have certain predictive value for the disease outcome in patients with HBGH.