骨痛灵酊对腰椎间盘突出症患者血清5-HT和β-EP水平的影响

Effect of Gutongling Tincture on Serum 5-HT andβ-EP Level in the Lumbar Disc Herniation Patients

目的探讨与分析骨痛灵酊对腰椎间盘突出症患者血清5-羟色胺(5-hydmzytryptamine,5-HT)和β-内啡肽(β-Endorphins,β-EP)水平的影响。方法选择2019年4月—2023年1月在新疆生产建设兵团医院城北分院诊治的120例腰椎间盘突出症患者作为研究对象,根据1:1随机抽签法把120例患者分为骨痛灵酊组60例与对照组60例。对照组给予常规药物治疗,骨痛灵酊组在对照组治疗的基础上给予骨痛灵酊治疗,连续治疗观察8周,检测两组患者血清5-羟色胺和β-内啡肽水平变化情况,判定临床疗效、腰屈曲范围与疼痛MPQ评分变化情况。结果治疗8周后骨痛灵酊组的疗效优良率显著高于对照组,差异有统计学意义(P<0.05)。两组治疗8周后的疼痛MPQ评分都明显低于治疗前,差异有统计学意义(P<0.05),骨痛灵酊组治疗8周后的疼痛MPQ评分与对照组相比明显降低,差异有统计学意义(P<0.05)。两组治疗8周后的腰屈曲范围都明显高于治疗前,差异有统计学意义(P<0.05),骨痛灵酊组治疗8周后的腰屈曲范围与对照组相比明显升高,差异有统计学意义(P<0.05)。两组治疗8周后的血清5-羟色胺、β-内啡肽含量低于治疗前,差异有统计学意义(P<0.05),骨痛灵酊组治疗8周后血清5-羟色胺、β-内啡肽含量与对照组相比也显著降低,差异有统计学意义(P<0.05)。结论骨痛灵酊在腰椎间盘突出症患者中的应用能抑制血清5-羟色胺、β-内啡肽的表达,能促进缓解疼痛,提高患者的总体治疗效果,还可改善患者的腰屈曲范围。

Objective To explore and analysis the effects of Gutongling tincture on serum 5-hydroxytryptamine(5-HT)andβ-Endorphins(β-EP)leveles in the Lumbar disc herniation patients.Methods From April 2019 to January 2023,120 cases of patients with lumbar disc herniation diagnosed and treated in Xinjiang Production and Construction Corps Hospital,Chengbei Branch were selected as the study subjects,and the 120 patients were divided into the Gutongling tincture group of 60 cases and the control group of 60 cases accorded to the 1:1 random drawing method.The control group were treated with conventional drugs,while the Gutongling tincture group were treated with Gutongling tincture on the basis of the control group's treatment.Continuous treatment observation were conducted for eight weeks in the two groups,and serum 5-HT andβ-EP levels were detected in both groups of patients,observed the clinical efficacy,the changes of range of lumbar flexion and pain MPQ score.Results After eight weeks of treatment,the excellent and good efficacy rate of the Gutongling tincture group were significantly higher than the control group(P<0.05).The pain MPQ scores of both groups after eight weeks of treatment were significantly lower than before treatment(P<0.05),while the pain MPQ scores of the Gutongling tincture group after eight weeks of treatment were significantly lower than those of the control group(P<0.05).After eight weeks of treatment,the range of lumbar flexion in both groups were significantly higher than before treatment(P<0.05),and the range of lumbar flexion in the Gutongling tincture group were significantly higher than that in the control group after eight weeks of treatment(P<0.05).The serum 5-HT andβ-EP levels after eight weeks of treatment in two groups were lower than that before treatment(P<0.05),and the serum 5-HT andβ-EP levels in the Gutongling tincture group were also decreased significantly compared with the control group(P<0.05).Conclusion The application of Gutongling tincture in patients with lumbar disc herniation can inhibit serum expression of 5-HT andβ-EP,it can promote pain relief,improve the overall therapeutic effect of patients,and also improve the range of lumbar flexion of patients.