间充质干细胞源性外泌体治疗脊髓损伤的研究进展

Research Progress on Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Spinal Cord Injury

脊髓损伤是严重的创伤性疾病,影响患者损伤部位及以下的运动、感觉与自主神经功能障碍。现有治疗手段单一、且效果不佳。间充质干细胞源性外泌体可通过调节炎症反应、改善血-脊髓屏障、减少细胞凋亡、促进轴突生长、修复瘢痕组织等方式,改善和治疗脊髓损伤造成的神经细胞功能障碍。因其在临床治疗应用上的潜力,间充质干细胞源性外泌体成为治疗脊髓损伤的研究热点。

Spinal cord injury is a severe traumatic disease that affects motor、sensory and autonomic dysfunction at and below the site of injury.Current treatment options are limited and often ineffective.Mesenchymal stem cell-derived exosomes have shown promise in improving and treating nerve cell dysfunction caused by spinal cord injury through regulating the inflammatory response,improving the blood-spinal barrier,reducing cell death,promoting axon growth,and repairing scar tissue.Due to their potential in clinical application,mesenchymal stem cell-derived exosomes are a hot topic in the treatment of spinal cord injury.