岩藻多糖调控肠道黏膜屏障功能及其在动物生产中的应用

Fucoidan regulates intestinal mucosal barrier function and its application in animal production

肠道是动物机体重要的免疫器官之一,肠道黏膜是机体内环境与外界直接接触和交流的主要场所,是机体抵御肠道抗原的第一道防线。肠道黏膜屏障的完整性是维持肠道正常功能和健康的前提。岩藻多糖是富含硫酸基团的大分子多糖,具有抗炎、抗氧化和抗病毒等功能,可以通过调节肠上皮屏障功能、胆汁的分泌、肠上皮细胞紧密连接、肠道菌群结构和免疫细胞功能维护肠道内环境的稳态。文章主要综述岩藻多糖对动物肠道黏膜屏障的影响及其在动物生产中的应用,旨在为新型饲料添加剂的开发提供参考。

The intestinal tract is one of the important immune organs of the animal body,the intestinal mucosa is the main place of direct contact and communication between the internal environment and the outside world,and is the first line of defense against intestinal antigens.The integrity of the intestinal mucosal barrier is a prerequisite for the maintenance of normal intestinal function and health.Fucoidan is a macromolecular polysaccharide rich in sulfate groups,which has antiinflammatory,antioxidant,and antiviral functions,and can maintain the homeostasis of the intestinal environment by regulating the intestinal epithelial barrier function,bile secretion,intestinal epithelial cell tight junction,intestinal microbiota structure,and immune cell function.This article mainly reviews the effect of fucoidan on the intestinal mucosal barrier of animals and its application in animal production,aiming to provide a reference for the development of new feed additives.