食用燕窝对促进认知影响的定性研究

Impact of Edible Bird ′s Nest on Cognition: A Qualitative Evidence-Based Study

目的:系统评价燕窝对认知的影响。方法:在中国知网、万方、中国生物医学文献数据库、PubMed和Embase数据库中检索自2012年9月1日—2022年9月1日国内外发表的相关研究文献,并根据纳入排除标准对文献进行筛选。参照SYRCLE动物实验风险评估工具,对相关文献进行综合评价。结果:共纳入5项研究,均为动物模型实验。无论燕窝的来源、给药途径、治疗时间、治疗目的(营养、治疗或预防)是否一致,综述结果都表明,燕窝可以改善实验动物的认知功能,用于诱导性认知功能障碍的治疗,作为子代的认知营养增强剂,对动物暴露于脑毒性物质后续产生的认知损伤具有预防保护作用,且呈现出剂量依赖效应。并且,燕窝的促进认知作用可能与燕窝或其有效成分可以增强抗氧化能力,降低神经炎症和氧化应激反应有关。结论:动物实验表明,燕窝具有促进认知的潜在功效,但因缺乏人群实验,尙无法确定燕窝对人群认知的影响。

【Objective】To systematically evaluate the efficacy of edible bird'nest on cognition.【Method】Relevant studies published from September 1st 2012 to September 1st 2022 on PubMed,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Database,and China Biology Medicine disc(CBMdisc)were searched and selected based on the predefined inclusion and exclusion criteria.The SYRCLE's risk of bias tool for animal studies was used to assess the bias of the selected studies.【Result】A total of 5 research were included,and all of them were animal studies.No matter the source of EBN,route of administration,duration of intervention,and aims of intervention(treatment or prevention),the findings of the systematic review supported that EBN could enhance the healthy and cognition-impaired animals'cognitive functions,act as a nutritional cognitive-enhancing agent in offspring and prevent cognitive damages from exposure to noxious cerebral accidents.In addition,there may exist dose-effects between EBN and cognitive-enhancing capacity.The potential mechanism of EBN's cognition promotion function is associated with EBN or its bioactive properties'ability to increase antioxidant capacity,decrease neuroinflammation and reduce oxidative stress.This systemic review did not proceed with meta-analysis.【Conclusion】Animal studies suggested that EBN had potential cognitive-enhancing impacts;however,the potential cognitive-enhancing impact of EBN on human-being is still unclear since there is a lack of human trials.