二仙汤结合温针灸治疗肾虚肝郁型卵巢早衰的临床研究

A clinical study of Erxian decoction combined with warm acupuncture and moxibustion in the treatment of premature ovarian failure with kidney deficiency and liver depression

目的:探讨二仙汤结合温针灸治疗肾虚肝郁型卵巢早衰的临床疗效。方法:将2019年12月31日―2021年1月1日临沂市中心医院诊疗的120例肾虚肝郁型卵巢早衰患者作为研究对象,随机将其分为中药组、西药组、针药组,每组40例,中药组采用二仙汤进行治疗,西药组采用常规西药进行治疗,针药组采用二仙汤结合温针灸进行治疗,对比三组患者血脂指标、性激素水平、窦卵泡计数(Antral Follicle Count,AFC)及临床疗效。结果:治疗前,三组患者促黄体生成素(Luteinizing Hormone,LH)、促卵泡生成素(Follicle-stimulating Hormone,FSH)、雌二醇(Estradiol,E_(2))、AFC水平对比无明显差异(P>0.05);治疗3个月及治疗6个月后,针药组患者LH、FSH明显低于中药组与西药组,E_(2)、AFC明显高于中药组与西药组(P<0.05)。治疗前,三组患者低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)、高密度脂蛋白胆固醇(High Density Lipoprotein Cholesterol,HDL-C)、三酰甘油(Triglyceride,TG)、总胆固醇(Total Cholesterol,TC)水平的差异无统计学意义(P>0.05);治疗3个月后及治疗6个月后,针药组LDL-C、HDL-C、TG及TC水平均明显低于中药组与西药组(P<0.05)。针药组总有效率明显高于中药组与西药组(P<0.05)。结论:采用二仙汤与温针灸联合治疗肾虚肝郁型卵巢早衰临床疗效显著,能够明显改善患者的性激素水平与血脂水平,应用价值较高。

Objective:To investigate the clinical effect of Erxian decoction(二仙汤)combined with warm acupuncture and moxibustion in the treatment of premature ovarian failure with kidney deficiency and liver depression.Methods:A total of 120 cases of premature ovarian failure with kidney deficiency and liver depression who were treated in Linyi Central Hospital from December 31,2019 to January 1,2021 were selected as the research subjects,and were randomly divided into the traditional Chinese medicine group,the Western medicine group and the acupuncture plus medicine group,with 40 cases in each group.The traditional Chinese medicine group was treated with Erxian decoction,the Western medicine group was treated with conventional Western medicine,and the acupuncture plus medicine group was treated with Erxian decoction plus warm acupuncture and moxibustion.Blood lipid index,sex hormone level,antral follicle count(AFC)and clinical efficacy were compared among the three groups.Results:Before treatment,there was no significant difference in the levels of luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E_(2))and AFC among the three groups(P>0.05).After 3 months and 6 months of treatment,LH and FSH in the acupuncture plus medicine group were significantly lower than those in the traditional Chinese medicine group and the Western medicine group,and E_(2) and AFC were significantly higher than those in the traditional Chinese medicine group and the Western medicine group(P<0.05).Before treatment,the levels of lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglyceride(TG)and total cholesterol(TC)in the three groups were not statistically significant different(P>0.05).After 3 months and 6 months of treatment,the levels of LDL-C,HDL-C,TG and TC in the acupuncture plus medicine were significantly lower than those in the traditional Chinese medicine group and the Western medicine group(P<0.05).The total effective rate in the acupuncture plus medicine group was 95.00%,which was significantly higher than that in the traditional Chinese medicine group and the Western medicine group(P<0.05).Conclusion:The combination of Erxian decoction and warm acupuncture and moxibustion has a significant clinical effect in the treatment of premature ovarian failure with kidney deficiency and liver depression,it can significantly improve the level of sex hormones and blood lipids,and has high application value.