孟鲁司特钠联合西替利嗪治疗慢性咳嗽患儿的效果

Efficacy of Montelukast sodium combined with Cetirizine in treatment of children with chronic cough

目的:观察孟鲁司特钠联合西替利嗪治疗慢性咳嗽患儿的效果。方法:回顾性分析2022年3月至2023年3月该院收治的70例慢性咳嗽患儿的临床资料,根据治疗方法不同分为研究组和对照组,每组35例。对照组给予孟鲁司特钠治疗,研究组在对照组基础上联合西替利嗪治疗,比较两组治疗总有效率、炎性因子水平、肺功能指标水平、症状消失时间及不良反应发生率。结果:治疗后,研究组治疗总有效率高于对照组,血清降钙素原、超敏C反应蛋白水平及红细胞沉降率均低于对照组,差异有统计学意义(P<0.05);研究组用力肺活量、第1秒用力呼气容积及第1秒用力呼气容积/用力肺活量均高于对照组,差异有统计学意义(P<0.05);研究组咳嗽症状明显缓解和消失时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:孟鲁司特钠联合西替利嗪治疗慢性咳嗽患儿,可有效改善肺功能,缓解咳嗽症状,控制炎症反应,提高治疗总有效率,且安全性较高,效果优于孟鲁司特钠单药治疗。

Objective:To observe efficacy of Montelukast sodium combined with Cetirizine in treatment of children with chronic cough.Methods:The clinical data of 70 children with chronic cough admitted to this hospital from March 2022 to March 2023 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,35 cases in each group.The control group was treated with Montelukast sodium,while the study group was treated with Cetirizine on the basis of that of the control group.The total effective rate of treatment,the inflammatory factor levels,the lung function index levels,the symptom disappearance time,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the total effective rate of treatment in the study group was higher than that in the control group,the levels of serum procalcitonin,hypersensitive C-reactive protein and erythrocyte sedimentation rate were lower than those in the control group,and the differences were statistically significant(P<0.05).The forced vital capacity,the forced expiratory volume in one second and the forced expiratory volume in one second/forced vital capacity in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The relief time and the disappearance time of cough symptoms in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Montelukast sodium combined with Cetirizine in the treatment of the children with chronic cough can effectively improve the lung function,relieve the cough symptoms,control the inflammatory response,improve the treatment efficiency,and has high safety.Moreover,it is superior to single Montelukast sodium treatment.