短波紫外线联合维生素B_(2)治疗再生障碍性贫血并发口腔黏膜炎患者的效果

Effects of short-wave ultraviolet combined with Vitamin B_(2) in treatment of aplastic anemia complicated with oral mucositis

目的:探讨短波紫外线联合维生素B_(2)治疗再生障碍性贫血(AA)并发口腔黏膜炎患者的效果。方法:选取2021年1月至2023年1月该院收治的85例AA并发口腔黏膜炎患者进行前瞻性研究,根据随机数字表法将其分为对照组42例和观察组43例。对照组外用维生素B_(2)片治疗,观察组在对照组基础上联合短波紫外线照射治疗。比较两组临床疗效,疼痛消失时间,溃疡愈合时间,治疗前后口腔黏膜炎每日自评问卷(OMDQ)评分、血清炎性因子[转化生长因子-β1(TGF-β1)、白细胞介素-6(IL-6)及超敏C反应蛋白(hs-CRP)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.35%(41/43),高于对照组的76.19%(32/42),差异有统计学意义(P<0.05);观察组疼痛消失时间、溃疡愈合时间均明显短于对照组,差异有统计学意义(P<0.05);治疗后,观察组OMDQ评分及血清TGF-β1、IL-6、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05);治疗期间,两组均未出现严重不良反应。结论:短波紫外线联合维生素B_(2)用于AA并发口腔黏膜炎患者可提高治疗总有效率,加快疼痛消失和溃疡愈合,降低炎性因子水平,效果优于单用维生素B_(2)治疗。

Objective:To investigate effects of short-wave ultraviolet combined with Vitamin B_(2) in treatment of patients with aplastic anemia(AA)complicated with oral mucositis.Methods:A prospective study was conducted on 85 patients with AA complicated with oral mucositis admitted to this hospital from January 2021 to January 2023.According to the random number table method,they were divided into control group(42 cases)and observation group(43 cases).The control group was treated with Vitamin B_(2) tablets for external use,while the observation group was treated with short-wave ultraviolet irradiation on the basis of that of the control group.The clinical efficacy,the pain disappearance time and the ulcer healing time,the oral mucositis daily questionnaire(OMDQ)score,the serum inflammatory factors[transforming growth factor-β1(TGF-β1),interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)]levels before and after the treatment,and the adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.35%(41/43),which was higher than 76.19%(32/42)of the control group,and the difference was statistically significant(P<0.05).The pain disappearance time and the ulcer healing time in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the OMDQ score and the serum levels of TGF-β1,IL-6 and hs-CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).During the treatment,there were no serious adverse reactions in the two groups.Conclusions:Short-wave ultraviolet combined with Vitamin B_(2) can improve the total effective rate of treatment in the patients with AA complicated with oral mucositis,accelerate the disappearance of pain and the ulcer healing,and reduce the levels of inflammatory factors.Moreover,it is superior to single Vitamin B_(2) treatment.