舒血宁注射液联合美托洛尔治疗老年冠心病心绞痛患者的效果

Effects of Shuxuening injection combined with Metoprolol in treatment of elderly patients with coronary heart disease and angina pectoris

目的:观察舒血宁注射液联合美托洛尔治疗老年冠心病心绞痛患者的效果。方法:选取2021年6月至2023年6月该院收治的78例老年冠心病心绞痛患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各39例。两组均进行常规治疗,在此基础上,对照组采用美托洛尔治疗,观察组在对照组基础上联合舒血宁注射液治疗,两组均治疗3周。比较两组临床疗效,治疗前后心绞痛发作次数、发作持续时间、疼痛[视觉模拟评分法(VAS)]评分、血管内皮功能指标[一氧化氮(NO)、血管内皮生长因子(VEGF)、内皮素-1(ET-1)、血栓素B2(TXB2)]水平,以及不良反应发生率。结果:观察组治疗总有效率为92.31%(36/39),高于对照组的74.36%(29/39),差异有统计学意义(P<0.05);治疗后,观察组心绞痛发作次数少于对照组,发作持续时间短于对照组,VAS评分低于对照组,差异有统计学意义(P<0.05);治疗后,观察组NO、VEGF水平均高于对照组,ET-1、TXB2水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:舒血宁注射液联合美托洛尔治疗老年冠心病心绞痛患者可提高治疗总有效率,减少心绞痛发作次数,降低VAS评分,缩短发作持续时间,改善血管内皮功能指标水平,效果优于单纯美托洛尔治疗。

Objective:To observe effects of Shuxuening injection combined with Metoprolol in treatment of elderly patients with coronary heart disease and angina pectoris.Methods:A prospective study was conducted on 78 elderly patients with coronary heart disease and angina pectoris admitted to this hospital from June 2021 to June 2023.According to the random number table method,they were divided into control group and observation group,39 cases in each group.Both groups received routine treatment.On this basis,the control group was treated with Metoprolol,while the observation group was treated with Shuxuening injection on the basis of that of the control group.Both groups were treated for 3 weeks.The clinical efficacy,the frequency and duration of angina pectoris attacks,the pain[visual analogue scale(VAS)]score,the vascular endothelial function indexes[nitric oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),thromboxane B2(TXB2)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.31%(36/39),which was higher than 74.36%(29/39)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the frequency of angina pectoris attacks in the observation group was less than that in the control group,the duration of the attack was shorter than that in the control group,the VAS score was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of NO and VEGF in the observation group were higher than those in the control group,the levels of ET-1 and TXB2 were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Shuxuening injection combined with Metoprolol in the treatment of the elderly patients with coronary heart disease and angina pectoris can improve the total effective rate of treatment,reduce the frequency of angina pectoris attacks and the VAS scores,shorten the duration of attacks,and improve the levels of vascular endothelial function indexes.Moreover,it is superior to single Metoprolol treatment.