基于“久病入络”理论探讨“虚”“痰”“瘀”与肺纤维化的关系

To Explore the Relationship between"Deficiency""Phlegm""Stasis"and Pulmonary Fibrosis based on the Theory of"Chronic Disease into Collaterals"

肺纤维化(pulmonary fibrosis, PF)是一种慢性、进行性、致死性的间质性肺疾病,是呼吸系统很难治愈的疾病之一。目前,西医治疗手段有限,只能在一定程度上控制疾病进展速度,而无法从根本上治愈PF。中医“久病入络”理论体现的是疾病复杂生变的病理过程,其中“虚”“痰”“瘀”是其重要的病理体现。中医认为,PF日久不愈,易致正气不足,肺气虚弱,肺络失养,从而进一步导致痰瘀互结,形成本虚标实之证,与“久病入络”密不可分。文章基于“久病入络”理论探讨“虚”“痰”“瘀”与PF的关系,以期从中医领域探索防治PF的可能手段,进一步扩展PF的治疗措施,为PF临床治疗提供参考,从而更好地改善预后,提高PF患者生活质量。

Pulmonary fibrosis is a chronic,progressive and fatal interstitial lung disease,which is one of the refractory respiratory diseases.At present,Western medicine has limited means of treatment,which can only control the progression of the disease to a certain extent,but can not fundamentally cure pulmonary fibrosis.The theory of"chronic disease entering collaterals"in traditional Chinese medicine reflects the pathological process of complex diseases,among which"deficiency","blood stasis"and"phlegm"are the important pathological manifestations.Traditional Chinese medicine believes that pulmonary fibrosis is not healed for a long time,easy to cause the deficiency of healthy qi,lung qi weakness,lung collateral loss,which further leads to phlegm and blood stasis mutual junction,the formation of the syndrome of deficiency and deficiency,and"chronic disease into collaterals"is inseparable.Therefore,based on the theory of"chronic disease into collaterals",this paper discusses the relationship between"deficiency","stasis","phlegm"and pulmonary fibrosis,in order to explore the possible means of prevention and treatment of pulmonary fibrosis from the field of traditional Chinese medicine,further expand the therapeutic measures of pulmonary fibrosis,and provide reference for the clinical treatment of pulmonary fibrosis,so as to better improve the prognosis and improve the quality of life of patients with pulmonary fibrosis.