李广文种子转阴丹治疗免疫性不孕

LI Guangwen's Zhong Zi Zhuan Yin Dan(种子转阴丹)for Treatment of Immunologic Infertility

不明原因不孕占比可达到不孕症10%~30%,其中免疫因素引起的不明原因不孕越来越引起临床的重视。免疫一词,顾名思义是免于疾病,亦即防病于未然之意。中医学在《黄帝内经》时期就有防病思想的萌芽,但并未形成系统的防治免疫性疾病理论。中医学典籍对免疫性不孕未有记载,根据其临床表现特点可归属“不孕”范畴。对免疫性不孕的诊治,可根据辨证求因,审因求治的原则进行论治。李广文教授根据中医基础理论,结合免疫性不孕的发病机制,提出本病以肾虚为本,房劳损伤、感染邪毒等为外所因,瘀血为主要致病因素,内外因相合,造成气血失调,阴阳相乘,冲任督带损伤,则胎孕难成。李广文教授自拟种子转阴丹,兼有双补气血、温肾助阳、解毒消抗功效,在临床取得良好疗效。但对种子转阴丹整个复方、单味中药及组方规律需要进一步深入的临床和基础研究,以阐明其在免疫性不孕中的作用机制。

The proportion of unexplained infertility can reach 10% to 30% of infertility,and unexplained infertility caused by immune factors is increasingly receiving clinical attention.The term'immunity',as the name suggests,means to be free from diseases,which also means to prevent diseases before they occur.During the period of the Huangdi Neijing in traditional Chinese medicine,there was a budding idea of disease prevention,but traditional Chinese medicine did not form a systematic theory for the prevention and treatment of immune diseases.There is no record of immunological infertility in traditional Chinese medicine.According to its clinical manifestations,it belongs to the category of"infertility"in traditional Chinese medicine.Based on the theory of traditional Chinese medicine and the pathogenesis of immunologic infertility,professor Li Guangwen put forward that this disease is based on kidney deficiency,which is internal cause.Sexual activity,infection with toxins,etc,are external causes.The combination of internal and external factors causes imbalance of Qi and blood,as well as disorder of Yin and Yang,leading to unability to conceive.Professor Li Guangwen developed Zhongzi Zhuanyin Dan(种子转阴丹)for immunologic infertility,which has dual effects of tonifying qi and blood,warming the kidney and aiding Yang,and detoxifying and anti-inflammatory effects,had achieved good clinical efficacy.However,further clinical and fundamental research is needed to elucidate the mechanism of the entire compound,single Chinese herbal medicine,and formula rules of Zhongzi Zhuanyin Dan(种子转阴丹)for treatment of immunologic infertility.