不同炮制方法对中药饮片草乌临床效果的影响

The Effect of Different Processing Methods on the Clinical Effect of Traditional Chinese Medicine Slices of Aconitum multiflorum

目的 探讨不同炮制方法对中药饮片草乌临床效果的影响。方法 选取2022年1月—2023年1月焦作市中医院收治的180例跟骨骨质增生患者,分为观察组和对照组,各90例。两组均采用物理疗法及复方马钱子酊剂进行外敷,其中对照组草乌采用传统炮制法炮制,观察组草乌采用加压蒸制法炮制。比较两组患者治疗前后跟骨疼痛分级指数(PRI)、现有疼痛强度(PPI)、视觉模拟评分(VAS)、炎性因子水平(血清白介素-6 [IL-6]、超敏C反应蛋白[hs-CRP]及肿瘤坏死因子-α[TNF-α])及生活质量,另外评价两组治疗效果。结果 治疗后,两组PRI、PPI及VAS评分均较前降低,观察组低于对照组;治疗后两组IL-6、hs-CRP及TNF-α水平均较治疗前下降,观察组IL-6、hs-CRP及TNF-α水平低于对照组;治疗后两组GQOLI74量表各项评分均较治疗前升高,观察组各项评分高于对照组;观察组治疗总有效率为97.78%,高于对照组的88.89%(P<0.05)。结论 不同炮制方法对中药饮片草乌的临床治疗效果影响不同。加压蒸制法炮制草乌,配伍组方复方马钱子酊剂,能够有效缓解跟骨骨质增生患者疼痛症状,解除患者痛苦,降低炎性因子水平,提高治疗有效率及生活质量,值得临床推广。

Objective To explore the effects of different processing methods on the clinical efficacy of herbal decoction pieces of Aconitum multiflorum.Method 180 patients with calcaneal bone hyperplasia admitted from Jiaozuo Traditional Chinese Medicine Hospital,January 2022 to January 2023 were selected and divided into an observation group and a control group,with 90 patients in each group.Both groups were treated with physical therapy and compound strychnine tincture for external application.The control group was processed using traditional processing methods,while the observation group was processed using pressure steaming method.Compare the calcaneal pain grading index(PRI),existing pain intensity(PPI),visual analogue score(VAS),and inflammatory factor levels[(serum interleukin-6(IL-6),hypersensitive C-reactive protein(hs CRP),and tumor necrosis factor(TNF-α)]between two groups of patients before and after treatment.Additionally,evaluate the treatment effectiveness and quality of life of both groups.Result After treatment,the PRI,PPI,and VAS scores of both groups decreased compared to before,and the observation group was lower than the control group;After treatment,the levels of IL-6,hs CRP,and TNF in both groups decreased compared to before treatment.The levels of IL-6,hs CRP,and TNF in the observation group were lower than those in the control group;After treatment,the scores on the GQOLI74 scale in both groups increased compared to before treatment,while the scores in the observation group were higher than those in the control group;The total effective rate of the observation group was 97.78%,higher than the control group's 88.89%,with statistically significant differences(P<0.05).Conclusion Different processing methods have different effects on the clinical treatment effect of herbal decoction pieces of Aconitum multiflorum.The pressure steaming method for processing Aconitum multiflorum,combined with the formula of Compound Strychnos tincture,can effectively alleviate pain symptoms in patients with calcaneal bone hyperplasia,relieve pain,reduce inflammatory factor levels,improve treatment effectiveness and quality of life,and is worthy of clinical promotion.