琥珀酸亚铁联合叶酸治疗因月经量过多导致育龄期女性单纯性缺铁性贫血的临床疗效观察

Clinical efficacy of ferrous succinate combined with folic acid in the treatment of simple iron deficiency anemia caused by excessive menstrual volume in women of childbearing age

目的 观察琥珀酸亚铁联合叶酸治疗因月经量过多导致育龄期女性单纯性缺铁性贫血的临床疗效。方法 83例因月经量过多导致单纯性缺铁性贫血的育龄期女性,采用随机数字表法将其分为对照组(41例)和观察组(42例)。对照组患者采用琥珀酸亚铁联合维生素C治疗,观察组患者采用琥珀酸亚铁联合叶酸治疗。对比两组患者治疗前后的血红蛋白、血清铁蛋白水平及治疗后的临床疗效、不良反应发生情况。结果 治疗前,两组患者的血红蛋白、血清铁蛋白水平相差甚微,不存在统计学意义(P>0.05);治疗后,观察组患者的血红蛋白(126.71±7.69)g/L、血清铁蛋白(39.48±4.39)μg/L高于对照组的(112.36±7.58)g/L、(32.58±4.81)μg/L,差异具有统计学意义(P<0.05)。观察组患者治疗总有效率97.62%高于对照组的80.49%,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率19.05%比对照组的39.02%低,差异具有统计学意义(P<0.05)。结论 对月经量过多导致单纯性缺铁性贫血的育龄期女性采用琥珀酸亚铁联合叶酸较联合维生素C治疗效果显著,可以明显提高其血红蛋白与血清铁蛋白水平,有效改善贫血症状,且不良反应发生率低,值得推广。

Objective To observe the clinical efficacy of ferrous succinate combined with folic acid in the treatment of simple iron deficiency anemia caused by excessive menstrual volume in women of childbearing age.Methods A total of 83 female patients of childbearing age with simple iron deficiency anemia caused by excessive menstrual volume were included in the study,and they were divided into a control group(41 cases)and an observation group(42 cases)by random number table method.The control group was treated with ferrous succinate combined with vitamin C,and the observation group was treated with ferrous succinate combined with folic acid.The levels of hemoglobin and serum ferritin before and after treatment,the clinical efficacy after treatment,and the occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was little difference in hemoglobin and serum ferritin levels between the two groups(P>0.05).After treatment,the observation group had hemoglobin of(126.71±7.69)g/L and serum ferritin of(39.48±4.39)μg/L,which were higher than(112.36±7.58)g/L and(32.58±4.81)μg/L in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 97.62%,which was higher than 80.49%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 19.05%,which was lower than 39.02%in the control group,and the difference was statistically significant(P<0.05).Conclusion Ferrous succinate combined with folic acid and vitamin C has significant effect on women of childbearing age with simple iron deficiency anemia caused by excessive menstrual volume,which can better improve the level of hemoglobin and serum ferritin,effectively improve the clinical symptoms of anemia,and the incidence of adverse reactions is low.It is worth popularizing.